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. Author manuscript; available in PMC: 2021 Sep 22.
Published in final edited form as: Bone. 2020 Mar 10;135:115317. doi: 10.1016/j.bone.2020.115317

Figure 3: The gut microbiota influences skeletal muscle mass and function in mice.

Figure 3:

(A) The consequence of gut microbiota depletion after antibiotic treatment for 21 days, results in muscle endurance activity as well as glucose metabolism was severely affected. (B) It compares the skeletal muscle phenotype and function between GF mice and PF mice. Compared to PF mice, GF mice have increased muscle atrophy and reduced muscle growth, mitochondrial oxidative activity and amino acid metabolism. Transplantation of GM from PF mice to GF mice improved the skeletal muscle mass and oxidative metabolic function. GM: Gut microbiota, GF: Germ-free, PF: Pathogen free mice.