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. 2021 Sep 8;8:706628. doi: 10.3389/fcvm.2021.706628

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Copyright © 2021 Franke, Brüning, Yevtushenko, Dreger, Brand, Juri, Unbehaun, Kempfert, Sündermann, Lembcke, Solowjowa, Kelle, Falk, Kuehne, Goubergrits and Schafstedde.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Central illustration describing the present study's design. The aim of this study was to validate a CT-based model for estimation of transvalvular pressure gradients (TPG_CT). CT images and pressure waveforms of 84 patients with aortic stenosis were investigated in this retrospective study. TPG_CT was calculated using a reduced-order model requiring the aortic flow rate (Q) and the aortic valve area (AVA) as input. AVA was calculated by segmentation of the aortic valve leaflets, and Q was calculated from volumetric assessment of the left ventricle. For validation, invasively measured TPG_catheter was calculated from pressure measurements in the left ventricle as well as the ascending aorta.