EC50 and Log P values of 1–5 in MDA-MB-231 cells in the dark, ECD50, and upon irradiation, ECI50 along with the phototherapeutic index (PI).
| Complex | ECD50a | ECI50a | PIb | Log Pc |
|---|---|---|---|---|
| 1 | >30 | >30 | — | d |
| 2 | >30 | >30 | — | −0.042 ± 0.010 |
| 3 | >30 | 7.0 ± 1.4 | >4.2 | −0.098 ± 0.002 |
| 4 | >30 | >30 | — | 0.50 ± 0.01 |
| 5 | >30 | 1.6 ± 0.3 | >19 | −0.29 ± 0.01 |
a
Average of three independent experiments.
b
PI = ECD50/ECI50.
c
Log P = octanol : water partition coefficient, determined by shake flask method, 298 ± 3 K, results are average of three independent experiments, errors are standard deviations.
d
Not determined.