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(A–C) Effect of chronic 4V OT infusions (16 nmol/day) and systemic beta-3 receptor agonist (CL 31643) administration (0.5 mg/kg) on UCP-1 content in IWAT, EWAT, and IBAT in male DIO rats. UCP-1 was analyzed from IWAT, EWAT, and IBAT (A–C) in DIO rats treated with 4V OT (16 nmol/day) or 4V vehicle in combination with IP CL 316243 (0.5 mg/kg) or IP vehicle. (A) IWAT. (B) EWAT. (C) IBAT. Data are expressed as mean ± SEM. *P < 0.05, †0.05 < P < 0.1.
