Table 2.
Comparison of characteristics in patients based on tumor microvascular invasion (MVI).
| All patients (n=370) |
MVI present (n=173) |
MVI absent (n=197) |
P-value | |
|---|---|---|---|---|
| Demographic and history | ||||
| Age | 65 (12) | 65 (13) | 66 (11) | 0.712 |
| Male | 271 (73%) | 130 (75%) | 141 (72%) | 0.481 |
| Child Pugh class B | 7 (2%) | 5 (3%) | 2 (1%) | 0.259 |
| Primary liver disease | ||||
| Hepatitis B | 93 (25%) | 50 (29%) | 43 (22%) | 0.346# |
| Hepatitis C | 68 (18%) | 30 (17%) | 38 (19%) | |
| Hepatitis B + C | 6 (2%) | 3 (2%) | 3 (2%) | |
| Alcoholic | 40 (11%) | 16 (9%) | 24 (12%) | |
| Hemochromatosis | 6 (2%) | 0 (0%) | 6 (3%) | |
| None | 157 (42%) | 74 (43%) | 83 (42%) | |
| Metabolic syndrome | 101 (27%) | 45 (26%) | 56 (28%) | 0.641 |
| Preoperative blood tests * | ||||
| AFP, ng/mL | 7799 (33988) | 15776 (48872) | 1087 (5056) | < 0.001 |
| Neutrophil, K/mcL | 4.3 (1.4) | 4.4 (1.4) | 4.2 (1.4) | 0.075 |
| Lymphocyte, K/mcL | 1.5 (0.6) | 1.5 (0.6) | 1.6 (0.7) | 0.139 |
| Monocyte, K/mcL | 0.4 (0.2) | 0.4 (0.2) | 0.4 (0.1) | 0.523 |
| Total bilirubin, mg/dL | 0.7 (0.4) | 0.7 (0.3) | 0.8 (0.4) | 0.319 |
| INR | 1.1 (0.2) | 1.1 (0.1) | 1.1 (0.2) | 0.151 |
| Creatinine, mg/dL | 1.1 (0.4) | 1.1 (0.5) | 1.1 (0.3) | 0.457 |
| AST, units/L | 59 (50) | 66 (55) | 53 (44) | 0.001 |
| Platelet, K/mcL | 236 (106) | 249 (112) | 225 (100) | 0.026 |
| Albumin, g/dL | 4.1 (0.4) | 4.1 (0.5) | 4.2 (0.4) | 0.018 |
| NLR | 3.3 (2.1) | 3.5 (1.9) | 3.2 (2.3) | 0.014 |
| PLR | 186 (135) | 199 (133) | 173 (136) | 0.016 |
| LMR | 4.3 (2.1) | 4.1 (2.2) | 4.5 (2.0) | 0.039 |
| PNI | 48.9 (5.9) | 48.0 (6.2) | 49.7 (5.5) | 0.009 |
| APRI | 0.8 (0.8) | 0.8 (0.9) | 0.8 (0.8) | 0.119 |
| ANRI | 14.9 (13.6) | 16.0 (14.5) | 13.9 (12.7) | 0.057 |
| Preoperative imaging | ||||
| Largest tumor, cm | 7.6 (4.7) | 8.9 (5.0) | 6.6 (4.1) | < 0.001 |
| Multiple nodules | 44 (12%) | 23 (13%) | 21 (11%) | 0.520 |
MVI microvascular invasion, AFP α-fetoprotein, INR international normalized ratio, AST aspartate aminotransferase. NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio, PNI prognostic nutritional index, APRI AST to platelet ratio index, ANRI AST to neutrophil ratio index. Categorical variables are expressed as frequency (percentage). Continuous variables are expressed as mean (standard deviation).
*
per 1 standard deviation increase.
#
p-value compares hepatitis B or C or both vs. no history of viral hepatitis. Bolded p-values indicate statistical significance.