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. 2021 Sep 22;16(9):e0257604. doi: 10.1371/journal.pone.0257604

Table 3. Differences between patients with SARS-CoV-2 pneumonia clinical course of ≤4 weeks and >4 weeks (long COVID) from a 6 months follow-up in primary care (2020).

Patient´s characteristics Follow-up Symptoms Follow-up in primary care
Sociodemographic ≤4 weeks >4 weeks p-value Symptoms ≤4 weeks >4 weeks p-value Primary Care ≤4 weeks >4 weeks p-value
n 111 44   Fever (>37,5°C)& 6 (5.4) 5 (11.1) 0.210 Days of follow-up$ 50.0 (39.0, 73.0) 81.0 (50.5, 103.0) <0.001
Sex (female)& 52 (46.8) 28 (63.6) 0.050 Cough& 37 (33.3) 28 (63.6) <0.001 Number of phone calls by GP or nurse during the follow-up# 10.6 (5.0) 16.0 (8.0) <0.001
Age (mean) & 60.1 (17.6) 55.7 (14.2) 0.140 Dyspnoea& 24 (21.6) 25 (54.6) <0.001 Blood Test, day 34.9 (25.5) 36.1 (13.6)  
Comorbidities       Myalgia& 10 (9.1) 12 (27.3) 0.004 Lymphocytes (10E3/ÂμL)$ 2492.6 (956.8) 2277.1 (789.7) 0.240
Overweight (BMI >25)& 61 (55.0) 22 (50.0) 0.370 Asthenia& 16 (14.4) 25 (56.8) <0.001 D-dimer (μg/L)$ 460.0 (260.0, 870.0) 465.0 (280.0, 730.0) 0.730
Hypertension& 59 (53.2) 12 (27.3) 0.004 Headache& 7 (6.3) 11 (25.0) 0.001 Ferritin (μg/L)$ 164.0 (42.0, 330.0) 143.0 (59.0, 410.0) 0.900
Dyslipidaemia& 45 (40.5) 15 (34.1) 0.460 Chest pain& 17 (15.3) 8 (18.2) 0.660 CRP (mg/L)$ 1.4 (0.3, 4.0) 1.2 (0.4, 2.9) 0.910
Type II Diabetes& 18 (16.2) 11 (25.0) 0.210 Dysgeusia& 2 (1.8) 1 (2.3) 0.850 Chest X-ray, day 51.4 (27.4) 56.7(33.3)  
Asthma& 17 (15.3) 3 (6.8) 0.150 Anosmia& 1 (0.9) 3 (7.0) 0.034 Normal X-ray& 71(64) 25 (55.6) 0.130
Smoke habit& 10 (9.0) 2(4.5) 0.630 GI symptoms& 23 (20.7) 18 (40.9) 0.010 COVID-19 Complications      
Chronic Kidney Disease& 10 (9.0) 1 (2.3) 0.140 Number of symptoms       ICU entry& 1 (0.9) 3 (6.8) 0.036
Cancer& 8 (7.2) 2 (4.5) 0.540 None& 27 (24.3) 0 (0.0) <0.001 Home Oxygen Therapy& 5 (4.5) 3 (6.8) 0.560
COPD& 5 (4.5) 1 (2.3) 0.520 ≤ 3& 63 (56.8) 24 (54.5) <0.001 Readmission& 6 (5.4) 3 (6.8) 0.730
Heart failure& 5 (4.5) 1 (2.3) 0.520 ≥ 4& 21 (18.9) 20 (45.5) <0.001 Thromboembolism& 2 (1.8) 4 (9.1) 0.034

&: number (%)

#: mean (standard deviation)

$: median (interquartile range), BMI (body mass index), COPD (chronic obstructive pulmonary disease), GI (gastrointestinal), ICU (intensive unit care), CRP (C reactive protein).