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. 2021 Sep 8;11:745584. doi: 10.3389/fonc.2021.745584

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Copyright © 2021 Wang, Chang, Zhang, Li, Wang, Yang, Pan, Zheng, Wang, Ou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioactivity-guided fractionation identifies ursolic acid as the bioactive compound of Oldenlandia diffusa against breast cancer. (A) Schematic illustration of the bioactivity-guided fractionation procedure. (B) MCF-7 and MDA-MB-231 cells were treated with different extracts of Oldenlandia diffusa (25~100 μg/ml) for 48 h CCK8 assay was conducted to investigate the survival rates of breast cancer cells. (C) The top 10 most abundant compounds in the F1 fraction were identified and quantified by LC-MS/MS. (D) MCF-7 and MDA-MB-231 cells were treated with 10 kinds of compounds (1~40 μM) for 48 h CCK8 assay was conducted to investigate the survival rates of breast cancer cells. (E) The expression change of Cav-1 protein in MCF-7 and MDA-MB-231 cells after treatment with 10 kinds of compounds (10 μM) for 48 h N = 3. ^* p < 0.05.