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. 2021 Sep 7;13(17):21513–21525. doi: 10.18632/aging.203491

Table 2. Prevalence and years of life lost by risk factors in men (left panel) and in women (right panel).

Risk factor Prevalence HR1 Years of life lost2 Risk factor Prevalence HR1 Years of life lost2
Year 95% CI Year 95% CI
High heart rate (≥ 90 beats/min) 6.4% 2.16 9.94 9.58 - 10.3 Proteinuria (Trace or Positive) 7.1% 2.44 10.14 9.93 - 10.35
Proteinuria (Trace or Positive) 7.9% 2.11 9.07 8.87 - 9.27 Diabetes (≥ 126 mg/dL) 4.8% 2.4 8.91 8.65 - 9.17
Diabetes (≥ 126 mg/dL) 5.7% 2.02 8.92 8.71 - 9.13 High heart rate (≥ 90 beats/min) 8.1% 2 8.89 8.49 - 9.29
Elevated WBC (≥ 9,000/mm3) 9.0% 1.82 7.49 7.11 - 7.87 Low GFR (< 60 ml/min/1.73 m2) 4.3% 1.78 7.32 7.1 - 7.54
Mild anemia (Hemoglobin 10 - 13.4 g/dL) 5.3% 1.56 7.47 7.24 - 7.7 Current smoker 6.7% 1.79 7.02 6.69 - 7.35
C-reactive protein (≥ 3 mg/L) 11.1% 1.84 7.37 7.11 - 7.63 Elevated WBC (≥ 9,000/mm3) 5.7% 1.9 6.63 6.32 - 6.94
Underweight (BMI <19 kg/m2) 6.3% 1.57 7.04 6.58 - 7.5 Regular drinker 2.4% 1.77 6.35 6.05 - 6.65
Regular drinker 12.1% 1.79 6.86 6.58 - 7.14 COPD 6.3% 1.45 6.01 5.76 - 6.26
COPD 7.3% 1.59 6.04 5.75 - 6.33 Long-duration sleep (> 8 h/day) 10.9% 1.44 5.34 5.02 - 5.66
Betel quid chewer 18.8% 1.82 6.00 5.66 - 6.34 Hypertension (DBP ≥ 90 mmHg) 17.6% 1.48 5.21 4.89 - 5.53
Current smoker 40.6% 1.69 5.66 5.35 - 5.97 Hypertension (SBP ≥ 140 mmHg) 16.4% 1.45 5.18 4.55 - 5.81
Restrictive lung disease 14.6% 1.55 5.47 5.19 - 5.75 Physical inactivity (<3.75 MET-h/wk) 59.9% 1.36 5.07 4.8 - 5.34
Long-duration sleep (> 8 h/day) 8.9% 1.43 5.04 4.75 - 5.33 Mild anemia (hemoglobin 10 - 12 g/dL) 10.2% 1.52 4.89 4.67 - 5.11
Physical inactivity (<3.75 MET-h/wk) 48.4% 1.55 4.74 4.45 - 5.03 C-reactive protein (≥ 3 mg/L) 10.5% 1.59 4.86 4.6 - 5.12
Hepatitis B carrier 17.4% 1.55 4.4 4.1 - 4.7 Restrictive lung disease 18.1% 1.45 4.79 4.54 - 5.04
Hypertension (SBP ≥ 140 mmHg) 19.1% 1.48 4.39 4.06 - 4.72 Low cholesterol (<160 mg/dL) 20.0% 1.6 4.66 4.21 - 5.11
Hypertension (DBP ≥ 90 mmHg) 22.0% 1.4 4.29 4.03 - 4.55 Underweight (BMI <18.5 kg/m2) 12.0% 1.46 4.25 3.53 - 4.97
Low cholesterol (<160 mg/dL) 17.0% 1.39 4.06 3.68 - 4.44 Low HDL-C (<35 mg/dL) 5.4% 1.4 4.25 4 - 4.5
Obesity (BMI ≥ 30 kg/m2) 4.3% 1.53 3.77 3.3 - 4.24 High uric acid (≥ 7 mg/dL) 8.5% 1.39 4.11 3.8 - 4.42
Low GFR (< 60 ml/min/1.73 m2) 6.0% 1.36 3.67 3.47 - 3.87 Elevated AST (≥ 25 U/L) 17.8% 1.48 3.71 3.5 - 3.92
Elevated AST (≥ 25 U/L) 35.9% 1.48 3.38 3.16 - 3.6 High triglyceride (≥ 200 mg/dL) 6.4% 1.43 3.43 3.15 - 3.71
Low blood glucose (< 90 mg/dL) 17.5% 1.31 3.32 3.06 - 3.58 Metabolic Syndrome (ATP III) 10.2% 1.43 3.16 2.98 - 3.34
High uric acid (≥ 8 mg/dL) 21.1% 1.23 2.64 2.3 - 2.98 Prolonged sitting (>8 hours/day) 61.9% 1.21 2.92 2.60 - 3.25
Low HDL-C (<35 mg/dL) 16.5% 1.25 2.52 2.26 - 2.78 Obesity (BMI ≥ 30 kg/m2) 3.6% 1.41 2.61 2.21 - 3.01
High triglyceride (≥ 200 mg/dL) 15.7% 1.21 2.51 2.24 - 2.78 Hepatitis B carrier 12.4% 1.35 2.17 1.86 - 2.48
Prolonged sitting (>8 hours/day) 55.8% 1.23 2.37 2.06 - 2.68 Pre-diabetes (110 - 125 mg/dL) 4.5% 1.13 1.11 0.85 - 1.37
Metabolic Syndrome (ATP III) 13.7% 1.26 2.36 2.16 - 2.56 Pre-Hypertension (SBP 120 - 139 mmHg) 21.7% 1.05 1.09 0.49 - 1.69
Pre-diabetes (110 - 125 mg/dL) 6.9% 1.15 1.62 1.4 - 1.84 High cholesterol (≥ 240 mg/dL) 10.2% 1.1 1.03 0.67 - 1.39
High cholesterol (≥ 240 mg/dL) 10.9% 1.13 0.91 0.55 - 1.27 Low blood glucose (< 90 mg/dL) 30.8% 1.13 0.82 0.48 - 1.16
Pre-Hypertension (SBP 120 - 139 mmHg) 36.7% 1.12 0.60 0.28 - 0.92

1HR: Age-adjusted hazard ratio.

2Life years lost: those with the risk – those without the risk.