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. 2021 Sep 7;13(17):21513–21525. doi: 10.18632/aging.203491

Table 3. Definition and cut-points of the 30 risk factors.

Risk factor* Risk group Reference group
High heart rate ≥ 90 beats/minute 60 - 69 beats/minute
Proteinuria Trace or positive (≥ 1+) (by dipstick) Negative
Diabetes Fasting blood glucose ≥ 126 mg/dL or on medication Fasting blood glucose 90 - 109 mg/dL
Elevated white blood cell (WBC) ≥ 9,000 / mm3 4000 - 5999/mm3
Mild anemia Hemoglobin 10 - 13.4 g/dL in men; 10 - 11 g/dL in women Hemoglobin 13.5 -15 g/dL in men;
12 - 14 g/dL in women
C-reactive protein ≥ 3.0 mg/L < 1 mg/L
Underweight Men: BMI < 19 kg/m2; Women: BMI < 18.5 kg/m2 BMI 23 - 24 kg/m2
Regular drinker Alcohol drinking: ≥ 2 drinks, ≥ 3 times a week Non-drinker
Chronic Obstructive Pulmonary Disease (COPD) GOLD definition: FEV1/FVC < 0.7 FEV1/FVC ≥ 0.7 and FVC ≥ 80%
Betel quid chewing Chewer Never chewer
Current smoker Current smoker Never smoker
Restrictive lung disease GOLD definition: FEV1/FVC ≥ 0.7, but FVC < 80% FEV1/FVC ≥ 0.7 and FVC ≥ 80%
Long-duration sleep Sleep duration > 8 hours/day Sleep duration 6 - 7 hours/day
Physical inactivity < 3.75 MET-h/wk (inactive) ≥ 7.5 MET-h/wk
Hepatitis B carrier (HBsAg) Hepatitis B surface antigen positive (HBsAg) Surface antigen negative
Hypertension (SBP) Systolic blood pressure ≥ 140 mmHg or on hypertension medication Systolic blood pressure 90 - 119 mmHg
Hypertension (DBP) Diastolic blood pressure ≥ 90 mmHg or on hypertension medication Diastolic blood pressure 60 - 79 mmHg
Low cholesterol Total cholesterol < 160 mg/dL Total cholesterol 180 - 199 mg/dL
Obesity BMI ≥ 30 kg/m2 BMI 23 - 24 kg/m2
Low glomerular filtration rate < 60 ml/min/1.73m2 (by CKD-EPI definition) 60 - 89 ml/min/1.73m2 (by CKD-EPI definition)
Elevated aspartate aminotransferase (AST) ≥ 25 U/L < 25 U/L
Low blood glucose Fasting blood glucose < 90 mg/dL Fasting blood glucose 90 - 109 mg/dL
High uric acid ≥ 7 mg/dL 5.0 – 5.9 mg/dL
Low HDL-C HDL-C < 35 mg/dL HDL-C 35 - 69 mg/dL
High triglyceride Triglyceride ≥ 200 mg/dL Triglyceride < 100 mg/dL
Prolonged sitting Yes (≥ 8 hours/day) No (< 8 hours/day)
Metabolic Syndrome (ATP III definition) When 3 or more of the following characteristics present:
Waistline ≥ 90 cm for men, or ≥ 80 cm for women
Triglyceride ≥ 150 mg/dL.
HDL-C <40 mg/dL for male, or <50 mg/dL for female.
Blood pressure ≥ 130 (SBP) / ≥ 85 (DBP) mm Hg.
Fasting blood glucose ≥ 110 mg/dL.
No metabolic syndrome
Pre-diabetes Fasting blood glucose 110 - 125 mg/dL Fasting blood glucose 90 - 109 mg/dL
High cholesterol Total cholesterol ≥ 240 mg/dL Total cholesterol 180 - 199 mg/dL
Pre-hypertension Systolic blood pressure 120 - 139 mmHg Systolic blood pressure 90 - 119 mmHg

*Listed in the order according to Table 2.