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. 2021 Sep 1;13(17):21294–21308. doi: 10.18632/aging.203459

Table 1. Correlation of PPM1D mRNA expression and prognosis in HCC with different characteristics by Kaplan-Meier plotter.

Characteristics OS (n = 364) PFS (n = 366) RFS (n = 313) DSS (n = 357)
N Hazard Ratio P-value N Hazard Ratio p-value N Hazard Ratio p-value N Hazard Ratio p-value
SEX
Male 246 1.87 (0.91–3.87) 0.085 246 1.52 (1.05–2.2) 0.027 208 1.62 (1.07–2.46) 0.023 241 1.87 (0.91–3.87) 0.085
Female 118 1.69 (0.87–3.27) 0.120 120 1.66 (0.98–2.8) 0.057 105 1.55 (0.84–2.84) 0.160 116 2.12 (1–4.45) 0.044
STAGE
1 170 1.56 (0.85–2.88) 0.150 170 2.31 (1.4–3.8) 0.000 153 2.19 (1.27–3.76) 0.004 167 2.72 (1.12–6.61) 0.021
2 83 1.71 (0.68–4.28) 0.250 84 0.8 (0.42–1.51) 0.490 74 0.67 (0.34–1.29) 0.230 82 2.55 (0.56–9.52) 0.21
3 83 0.65 (0.36–1.18) 0.150 83 0.75 (0.44–1.29) 0.300 68 0.78 (0.42–1.47) 0.440 81 0.65 (0.32–1.34) 0.24
4 5
AJCC_T
1 180 1.54 (0.86–2.77) 0.140 180 2.18 (1.34–3.54) 0.001 160 2.06 (1.22–3.49) 0.006 177 2.25 (1.01–5.04) 0.042
2 90 1.8 (0.73–4.42) 0.190 92 0.77 (0.42–1.41) 0.400 79 0.68 (0.36–1.27) 0.220 89 2.95 (0.67–12.9) 0.13
3 78 0.58 (0.31–1.09) 0.086 78 1.57 (0.76–3.25) 0.220 65 0.76 (0.4–1.44) 0.390 75 0.52 (0.23–1.18) 0.11
4 13 13 6 13
Vascular invasion
None 203 1.72 (1.03–2.87) 0.036 204 2.11 (1.33–3.35) 0.001 175 1.95 (1.21–3.15) 0.006 200 1.81 (0.88–3.71) 0.099
Micro 90 2.14 (0.93–4.93) 0.066 91 1.41 (0.79–2.49) 0.240 81 0.52 (0.26–1.01) 0.050 88 2.45 (0.76–7.97) 0.12
Race
white 181 0.73 (0.45–1.18) 0.190 183 1.45 (0.98–2.16) 0.060 147 1.41 (0.9–2.21) 0.130 177 1.34 (0.71–2.52) 0.37
Asian 155 1.9 (1.03–3.49) 0.035 155 1.8 (1.12–2.88) 0.014 143 2.01 (1.2–3.36) 0.007 152 5.57 (1.31–9.65) 0.0086
Hepatitis virus
Yes 150 2.17 (1.11–4.28) 0.021 152 1.97 (1.24–3.12) 0.003 138 2.07 (1.26–3.4) 0.003 149 2.75 (1.13–6.69) 0.02
None 167 1.54 (0.97–2.44) 0.067 167 1.54 (0.97–2.44) 0.067 142 0.72 (0.43–1.18) 0.190 163 2 (0.99–4.05) 0.049