Table 1. Correlation of PPM1D mRNA expression and prognosis in HCC with different characteristics by Kaplan-Meier plotter.
Characteristics | OS (n = 364) | PFS (n = 366) | RFS (n = 313) | DSS (n = 357) | ||||||||
N | Hazard Ratio | P-value | N | Hazard Ratio | p-value | N | Hazard Ratio | p-value | N | Hazard Ratio | p-value | |
SEX | ||||||||||||
Male | 246 | 1.87 (0.91–3.87) | 0.085 | 246 | 1.52 (1.05–2.2) | 0.027 | 208 | 1.62 (1.07–2.46) | 0.023 | 241 | 1.87 (0.91–3.87) | 0.085 |
Female | 118 | 1.69 (0.87–3.27) | 0.120 | 120 | 1.66 (0.98–2.8) | 0.057 | 105 | 1.55 (0.84–2.84) | 0.160 | 116 | 2.12 (1–4.45) | 0.044 |
STAGE | ||||||||||||
1 | 170 | 1.56 (0.85–2.88) | 0.150 | 170 | 2.31 (1.4–3.8) | 0.000 | 153 | 2.19 (1.27–3.76) | 0.004 | 167 | 2.72 (1.12–6.61) | 0.021 |
2 | 83 | 1.71 (0.68–4.28) | 0.250 | 84 | 0.8 (0.42–1.51) | 0.490 | 74 | 0.67 (0.34–1.29) | 0.230 | 82 | 2.55 (0.56–9.52) | 0.21 |
3 | 83 | 0.65 (0.36–1.18) | 0.150 | 83 | 0.75 (0.44–1.29) | 0.300 | 68 | 0.78 (0.42–1.47) | 0.440 | 81 | 0.65 (0.32–1.34) | 0.24 |
4 | 5 | – | – | – | – | – | – | – | – | – | – | – |
AJCC_T | ||||||||||||
1 | 180 | 1.54 (0.86–2.77) | 0.140 | 180 | 2.18 (1.34–3.54) | 0.001 | 160 | 2.06 (1.22–3.49) | 0.006 | 177 | 2.25 (1.01–5.04) | 0.042 |
2 | 90 | 1.8 (0.73–4.42) | 0.190 | 92 | 0.77 (0.42–1.41) | 0.400 | 79 | 0.68 (0.36–1.27) | 0.220 | 89 | 2.95 (0.67–12.9) | 0.13 |
3 | 78 | 0.58 (0.31–1.09) | 0.086 | 78 | 1.57 (0.76–3.25) | 0.220 | 65 | 0.76 (0.4–1.44) | 0.390 | 75 | 0.52 (0.23–1.18) | 0.11 |
4 | 13 | – | – | 13 | – | – | 6 | – | – | 13 | – | – |
Vascular invasion | ||||||||||||
None | 203 | 1.72 (1.03–2.87) | 0.036 | 204 | 2.11 (1.33–3.35) | 0.001 | 175 | 1.95 (1.21–3.15) | 0.006 | 200 | 1.81 (0.88–3.71) | 0.099 |
Micro | 90 | 2.14 (0.93–4.93) | 0.066 | 91 | 1.41 (0.79–2.49) | 0.240 | 81 | 0.52 (0.26–1.01) | 0.050 | 88 | 2.45 (0.76–7.97) | 0.12 |
Race | ||||||||||||
white | 181 | 0.73 (0.45–1.18) | 0.190 | 183 | 1.45 (0.98–2.16) | 0.060 | 147 | 1.41 (0.9–2.21) | 0.130 | 177 | 1.34 (0.71–2.52) | 0.37 |
Asian | 155 | 1.9 (1.03–3.49) | 0.035 | 155 | 1.8 (1.12–2.88) | 0.014 | 143 | 2.01 (1.2–3.36) | 0.007 | 152 | 5.57 (1.31–9.65) | 0.0086 |
Hepatitis virus | ||||||||||||
Yes | 150 | 2.17 (1.11–4.28) | 0.021 | 152 | 1.97 (1.24–3.12) | 0.003 | 138 | 2.07 (1.26–3.4) | 0.003 | 149 | 2.75 (1.13–6.69) | 0.02 |
None | 167 | 1.54 (0.97–2.44) | 0.067 | 167 | 1.54 (0.97–2.44) | 0.067 | 142 | 0.72 (0.43–1.18) | 0.190 | 163 | 2 (0.99–4.05) | 0.049 |