Table 3. Correlation analysis between PPM1D and related genes and markers of immune cells in TIMER.
Description | Gene markers | HCC | CHOL | ||||||
None | Purity | None | Purity | ||||||
Core | P | Core | P | Core | P | Core | P | ||
CD8+ T cell | CD8A | 0.17 | ** | 0.254 | *** | 1.107 | 0.533 | 0.019 | 0.914 |
CD8B | 0.07 | 0.18 | 0.15 | ** | 0.073 | 0.673 | 0.003 | 0.987 | |
T cell (general) | CD3D | 0.03 | 0.59 | 0.1 | 0.06 | 0.232 | 0.173 | 0.152 | 0.385 |
CD3E | 0.1 | 0.06 | 0.206 | *** | 0.172 | 0.315 | 0.066 | 0.705 | |
CD2 | 0.08 | 0.12 | 0.182 | *** | 0.151 | 0.377 | 0.046 | 0.791 | |
B cell | CD19 | 0.18 | *** | 0.222 | *** | 0.307 | 0.068 | 0.243 | 0.160 |
CD79A | 0.14 | ** | 0.238 | *** | 0.287 | 0.090 | 0.221 | 0.203 | |
Monocyte | CD86 | 0.27 | *** | 0.392 | *** | 0.127 | 0.460 | 0.023 | 0.897 |
CSF1R | 0.21 | *** | 0.326 | *** | 0.172 | 0.315 | 0.100 | 0.568 | |
TAM | CCL2 | 0.19 | *** | 0.295 | *** | 0.281 | 0.096 | 0.246 | 0.155 |
CD68 | 0.18 | *** | 0.255 | *** | 0.181 | 0.289 | 0.132 | 0.449 | |
IL10 | 0.23 | *** | 0.324 | *** | 0.251 | 0.140 | 0.158 | 0.364 | |
Ml Macro-phage | NOS2 | 0.21 | *** | 0.223 | *** | 0.307 | 0.069 | 0.312 | 0.068 |
IRF5 | 0.39 | *** | 0.381 | *** | 0.219 | 0.199 | 0.179 | 0.304 | |
PTGS2 | 0.28 | *** | 0.404 | *** | 0.383 | 0.021 | 0.338 | 0.046 | |
M2 Macro-phage | CD163 | 0.28 | *** | 0.393 | *** | 0.392 | 0.018 | 0.343 | 0.044 |
VSIG4 | 0.18 | *** | 0.285 | *** | 0.28 | 0.099 | 0.216 | 0.213 | |
MS4A4A | 0.22 | *** | 0.33 | *** | 0.286 | 0.091 | 0.21 | 0.227 | |
Natural killer cell | KIR2DL1 | 0.06 | 0.23 | 0.058 | 0.28 | -0.202 | 0.237 | –0.239 | 0.166 |
KIR2DL3 | 0.18 | *** | 0.217 | *** | -0.015 | 0.929 | –0.04 | 0.818 | |
KIR2DL4 | 0.12 | 0.02 | 0.152 | ** | -0.214 | 0.211 | –0.272 | 0.114 | |
KIR3DL1 | 0.13 | 0.01 | 0.157 | ** | -0.124 | 0.471 | –0.158 | 0.364 | |
KIR3DL2 | 0.08 | 0.12 | 0.130 | 0.02 | -0.105 | 0.542 | –0.113 | 0.516 | |
KIR3DL3 | 0.04 | 0.5 | 0.017 | 0.75 | -0.191 | 0.265 | –0.225 | 0.193 | |
KIR2DS4 | 0.09 | 0.08 | 0.099 | 0.07 | -0.114 | 0.507 | –0.149 | 0.392 | |
Dendritic cell | HLA-DPB1 | 0.16 | ** | 0.253 | *** | 0.088 | 0.608 | –0.004 | 0.982 |
HLA-DQB1 | 0.07 | 0.21 | 0.147 | ** | 0.311 | 0.066 | 0.269 | 0.118 | |
HLA-DRA | 0.22 | *** | 0.321 | *** | 0.071 | 0.681 | –0.033 | 0.850 | |
HLA-DPA1 | 0.22 | *** | 0.322 | *** | 0.056 | 0.743 | –0.048 | 0.783 | |
BDCA-1 | 0.19 | *** | 0.263 | *** | 0.136 | 0.428 | 0.052 | 0.767 | |
BDCA-4 | 0.51 | *** | 0.541 | *** | 0.515 | ** | 0.484 | ** | |
CD11c | 0.27 | *** | 0.356 | *** | 0.288 | 0.089 | 0.219 | 0.206 | |
Th1 | TBX21 | 0.10 | 0.05 | 0.176 | ** | 0.147 | 0.390 | 0.033 | 0.852 |
STAT4 | 0.18 | *** | 0.232 | *** | 0.099 | 0.564 | 0.04 | 0.820 | |
STAT1 | 0.41 | *** | 0.446 | *** | 0.4 | * | 0.379 | * | |
TNF | 0.12 | 0.02 | 0.187 | *** | 0.037 | 0.83 | –0.067 | 0.703 | |
INF-α | 0.22 | *** | 0.309 | *** | 0.319 | 0.059 | 0.294 | 0.087 | |
Th2 | GATA3 | 0.16 | ** | 0.280 | *** | 0.046 | 0.79 | –0.082 | 0.638 |
STAT6 | 0.39 | *** | 0.366 | *** | 0.529 | ** | 0.548 | *** | |
STAT5A | 0.35 | *** | 0.404 | *** | 0.228 | 0.181 | 0.196 | 0.258 | |
IL13 | 0.09 | 0.08 | 0.097 | 0.07 | 0.04 | 0.818 | –0.011 | 0.95 | |
Tfh | BCL6 | 0.41 | *** | 0.401 | *** | 0.407 | * | 0.4 | * |
IL21 | 0.12 | 0.02 | 0.162 | ** | 0.326 | 0.053 | 0.286 | 0.095 | |
Th17 | STAT3 | 0.49 | *** | 0.528 | *** | 0.547 | *** | 0.557 | *** |
IL17A | 0.1 | 0.06 | 0.107 | 0.05 | 0.053 | 0.759 | 0.005 | 0.979 | |
Treg | FOXP3 | 0.3 | *** | 0.335 | *** | 0.264 | 0.12 | 0.189 | 0.277 |
CCR8 | 0.43 | *** | 0.513 | *** | 0.344 | * | 0.293 | 0.088 | |
STAT5B | 0.74 | *** | 0.731 | *** | 0.642 | *** | 0.637 | *** | |
TGFB1 | 0.21 | *** | 0.297 | *** | 0.307 | 0.069 | 0.265 | 0.124 | |
T cell exhaustion | PD-1 | 0.14 | ** | 0.198 | *** | 0.203 | 0.234 | 0.157 | 0.369 |
CTLA4 | 0.11 | 0.03 | 0.186 | *** | 0.225 | 0.186 | 0.171 | 0.325 | |
LAG3 | 0.11 | 0.04 | 0.149 | ** | 0.08 | 0.64 | 0.005 | 0.977 | |
TIM-3 | 0.23 | *** | 0.351 | *** | 0.126 | 0.464 | 0.036 | 0.839 | |
GZMB | 0.04 | 0.43 | 0.075 | 0.17 | 0.039 | 0.823 | –0.058 | 0.742 |