Table 1. Network differential connectivity analysis.

Metabolite	pval_corr	pval_mi
Glutathione	0.06	0.02
1-Methyladenosine	0.14	0.04
Hippuric acid	0.02	0.06
Dephospho-CoA	0.02	0.06
Atractyloside B	0.04	0.16
Oxidized glutathione	0.04	0.24
Pantothenic acid	0.04	0.36
L-Malic acid	0.04	0.56
2′-O-methylaenosine monophosphate	0.02	0.86

Network differential connectivity analysis results of two networks built by the metabolomic data from young (A, n = 7) and old (B, n = 8) mouse kidney tissues. P-values were calculated based on the permutation in the algorithm. Correlation and mutual information were implemented for the analysis as previously described [47], and the p-values from each method using either correlation coefficient or mutual information referred to as pval_corr and pval_mi. Only the metabolites with p-values below 0.05 determined via any method are shown above.