Table 1. Correlation analysis between ACE2 expression and different immune cell type markers.
| Gene markers | Basal-like | Luminal | HER2 enriched | ||||||||||||||||||
| None | Purity | Age | None | Purity | Age | None | Purity | Age | |||||||||||||
| COR | P | COR | P | COR | P | COR | P | COR | P | COR | P | COR | P | COR | P | COR | P | ||||
| B cells | FCRL2 | 0.044 | 6.0E-01 | -0.091 | 3.1E-01 | 0.049 | 5.7E-01 | 0.227 | 1.3E-08 | 0.111 | 9.5E-03 | 0.212 | 1.3E-07 | 0.145 | 2.4E-01 | -0.006 | 9.7E-01 | 0.142 | 2.7E-01 | ||
| CD19 | 0.088 | 3.0E-01 | -0.032 | 7.2E-01 | 0.093 | 2.8E-01 | 0.230 | 7.4E-09 | 0.115 | 7.4E-03 | 0.218 | 5.6E-08 | 0.080 | 5.2E-01 | -0.090 | 5.0E-01 | 0.050 | 7.0E-01 | |||
| MS4A1 | 0.029 | 7.3E-01 | -0.121 | 1.7E-01 | 0.041 | 6.3E-01 | 0.249 | 3.5E-10 | 0.125 | 3.6E-03 | 0.241 | 1.7E-09 | 0.110 | 3.8E-01 | -0.035 | 7.9E-01 | 0.069 | 5.9E-01 | |||
| CD8+ T cells | CD8A | 0.124 | 1.5E-01 | 0.057 | 5.3E-01 | 0.120 | 1.6E-01 | 0.244 | 8.0E-10 | 0.132 | 2.0E-03 | 0.234 | 5.6E-09 | -0.087 | 4.9E-01 | -0.173 | 2.0E-01 | -0.079 | 5.4E-01 | ||
| CD8B | 0.126 | 1.4E-01 | 0.084 | 3.5E-01 | 0.133 | 1.2E-01 | 0.262 | 4.1E-11 | 0.158 | 2.2E-04 | 0.253 | 2.4E-10 | -0.067 | 5.9E-01 | -0.177 | 1.8E-01 | -0.067 | 6.0E-01 | |||
| Neutrophils | FCGR3B | 0.159 | 6.0E-02 | 0.145 | 1.0E-01 | 0.155 | 6.8E-02 | 0.085 | 3.6E-02 | 0.070 | 1.0E-01 | 0.091 | 2.6E-02 | 0.264 | 3.1E-02 | 0.240 | 7.0E-02 | 0.266 | 3.5E-02 | ||
| CEACAM3 | 0.073 | 3.9E-01 | -0.058 | 5.2E-01 | 0.076 | 3.8E-01 | 0.195 | 1.1E-06 | 0.131 | 2.3E-03 | 0.194 | 1.4E-06 | 0.223 | 7.0E-02 | 0.252 | 5.7E-02 | 0.226 | 7.6E-02 | |||
| SIGLEC5 | 0.232 | 5.8E-03 | 0.186 | 3.6E-02 | 0.225 | 7.9E-03 | 0.065 | 1.1E-01 | -0.021 | 6.2E-01 | 0.060 | 1.4E-01 | -0.088 | 4.8E-01 | -0.138 | 3.0E-01 | -0.118 | 3.6E-01 | |||
| FPR1 | 0.171 | 4.4E-02 | 0.117 | 1.9E-01 | 0.165 | 5.3E-02 | 0.148 | 2.2E-04 | 0.042 | 3.3E-01 | 0.143 | 4.0E-04 | -0.112 | 3.7E-01 | -0.180 | 1.8E-01 | -0.122 | 3.4E-01 | |||
| CSF3R | 0.260 | 1.9E-03 | 0.242 | 5.9E-03 | 0.253 | 2.6E-03 | 0.059 | 1.5E-01 | 0.028 | 5.2E-01 | 0.065 | 1.1E-01 | -0.117 | 3.5E-01 | -0.126 | 3.5E-01 | -0.155 | 2.3E-01 | |||
| S100A12 | 0.129 | 1.3E-01 | 0.107 | 2.3E-01 | 0.126 | 1.4E-01 | 0.206 | 2.6E-07 | 0.164 | 1.3E-04 | 0.211 | 1.6E-07 | 0.203 | 9.9E-02 | 0.149 | 2.6E-01 | 0.158 | 2.2E-01 | |||
| Macrophages | CD68 | 0.168 | 4.8E-02 | 0.095 | 2.9E-01 | 0.158 | 6.4E-02 | 0.063 | 1.2E-01 | -0.028 | 5.2E-01 | 0.060 | 1.4E-01 | 0.063 | 6.1E-01 | -0.024 | 8.6E-01 | 0.045 | 7.3E-01 | ||
| CD84 | 0.135 | 1.1E-01 | 0.079 | 3.8E-01 | 0.128 | 1.3E-01 | 0.135 | 8.1E-04 | 0.036 | 4.0E-01 | 0.129 | 1.4E-03 | 0.028 | 8.2E-01 | 0.025 | 8.5E-01 | -0.026 | 8.4E-01 | |||
| CD163 | 0.185 | 2.8E-02 | 0.148 | 9.6E-02 | 0.176 | 3.9E-02 | 0.110 | 6.2E-03 | 0.032 | 4.5E-01 | 0.110 | 6.5E-03 | 0.008 | 9.5E-01 | -0.078 | 5.6E-01 | -0.021 | 8.7E-01 | |||
| MS4A4A | 0.228 | 6.9E-03 | 0.189 | 3.3E-02 | 0.219 | 9.5E-03 | 0.161 | 6.2E-05 | 0.062 | 1.5E-01 | 0.158 | 9.2E-05 | -0.017 | 8.9E-01 | -0.116 | 3.9E-01 | -0.016 | 9.0E-01 | |||
| Dendritic cells | CD209 | 0.103 | 2.3E-01 | 0.023 | 8.0E-01 | 0.099 | 2.5E-01 | 0.195 | 1.0E-06 | 0.089 | 3.8E-02 | 0.188 | 3.2E-06 | 0.037 | 7.6E-01 | -0.045 | 7.4E-01 | 0.041 | 7.5E-01 | ||
| NK cells | KIR3DL3 | 0.012 | 8.9E-01 | -0.032 | 7.2E-01 | 0.020 | 8.1E-01 | 0.101 | 1.2E-02 | 0.052 | 2.2E-01 | 0.075 | 6.5E-02 | -0.045 | 7.2E-01 | -0.118 | 3.8E-01 | -0.053 | 6.8E-01 | ||
| NCR1 | 0.143 | 9.1E-02 | 0.085 | 3.4E-01 | 0.139 | 1.0E-01 | 0.178 | 9.2E-06 | 0.097 | 2.4E-02 | 0.173 | 1.8E-05 | -0.073 | 5.6E-01 | -0.111 | 4.1E-01 | -0.073 | 5.7E-01 | |||
| Th1 cells | TBX21 | 0.160 | 5.9E-02 | 0.087 | 3.3E-01 | 0.156 | 6.7E-02 | 0.244 | 8.0E-10 | 0.132 | 2.1E-03 | 0.237 | 3.7E-09 | -0.041 | 7.4E-01 | -0.122 | 3.6E-01 | -0.050 | 7.0E-01 | ||
| Treg | FOXP3 | 0.119 | 1.6E-01 | 0.033 | 7.1E-01 | 0.120 | 1.6E-01 | 0.191 | 1.9E-06 | 0.086 | 4.4E-02 | 0.185 | 4.6E-06 | -0.073 | 5.6E-01 | -0.158 | 2.4E-01 | -0.048 | 7.1E-01 | ||
| CCR8 | 0.144 | 9.0E-02 | 0.120 | 1.8E-01 | 0.142 | 9.5E-02 | 0.121 | 2.6E-03 | 0.062 | 1.5E-01 | 0.119 | 3.4E-03 | -0.226 | 6.6E-02 | -0.312 | 1.7E-02 | -0.258 | 4.1E-02 | |||
| Monocyte | C3AR1 | 0.224 | 7.8E-03 | 0.174 | 5.0E-02 | 0.214 | 1.1E-02 | 0.075 | 6.4E-02 | -0.026 | 5.5E-01 | 0.070 | 8.3E-02 | -0.050 | 6.9E-01 | -0.092 | 4.9E-01 | -0.061 | 6.4E-01 | ||
| CD86 | 0.212 | 1.2E-02 | 0.160 | 7.2E-02 | 0.204 | 1.6E-02 | 0.102 | 1.1E-02 | -0.010 | 8.2E-01 | 0.099 | 1.4E-02 | -0.066 | 6.0E-01 | -0.143 | 2.9E-01 | -0.069 | 5.9E-01 | |||
| CSF1R | 0.206 | 1.5E-02 | 0.127 | 1.5E-01 | 0.200 | 1.8E-02 | 0.105 | 8.8E-03 | -0.051 | 2.4E-01 | 0.096 | 1.8E-02 | -0.038 | 7.6E-01 | -0.101 | 4.5E-01 | -0.063 | 6.3E-01 | |||
NK cells, Natural killer cells; Th 1 cells, type I helper T cells; Treg, regulatory T cells; COR, r value of Spearman’s correlation; Purity, correlation adjusted by purity; Age correlation adjusted by age.