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Sequence analysis and homology modeling of the HDAC8 mutant. (a) Partial protein alignment (aa 96–115) showing the conservation of the Thr119 residue (highlighted in red). (b) Residue 119 is shown as van der Waals spheres, the residues defining the binding and catalytic cavity are shown in licorice, and the zinc atom is shown as a yellow sphere. The position where Arg119 contacts the residue 140 adjacent to binding pocket residue is highlighted by a red circle
