TABLE 2.
Associations of CNR1 alleles and genotypes between MDD cases and controls
| SNP | Genotypes | Genotype (subject size) | Allele frequency (%) | Chi‐square | OR (95%CI) | p value/p‐adjusted | ||
|---|---|---|---|---|---|---|---|---|
| Cases (n = 181) | HC (n = 80) | Cases | HC | |||||
| rs806366 | CC/CT/TT | 28/86/67 | 10/36/34 | C 39.4 | 34.9 | 0.91 | 1.21 (0.82, 1.80) | .37/.22 |
| rs806367 | TT/TC/CC | 3/41/137 | 0/5/75 | T 12.9 | 3.2 | 11.52 | 4.52 (1.76, 11.61) | .00034/.0020 |
| rs806368 | TT/TC/CC | 41/90/50 | 17/40/23 | T 47.8 | 45.6 | 0.20 | 1.09 (0.75, 1.58) | .70/.45 |
| rs806370 | CC/CT/TT | 39/90/52 | 16/39/25 | C 46.3 | 44.1 | 0.21 | 1.09 (0.75, 1.60) | .52/.48 |
| rs806380 | GG/GA/AA | 5/49/127 | 1/19/60 | G 16.2 | 13.6 | 0.10 | 0.96 (0.60, 1.53) | .77/.66 |
| rs6454674 | GG/GT/TT | 19/80/82 | 3/26/51 | G 32.8 | 20.4 | 7.90 | 1.90 (1.21, 2.99) | .0054/.0068 |
| rs2180619 | GG/GA/AA | 9/61/111 | 2/20/58 | G 21.6 | 15.0 | 3.08 | 1.56 (0.95, 2.58) | .093/.059 |
| MDNTR (n = 100) | HC (n = 80) | MDNTR | HC | |||||
|---|---|---|---|---|---|---|---|---|
| rs806366 | CC/CT/TT | 19/49/32 | 10/36/34 | C 43.2 | 34.9 | 2.48 | 1.42 (0.92, 2.20) | .12/.090 |
| rs806367 | TT/TC/CC | 0/13/87 | 0/5/75 | T 6.7 | 3.2 | 2.25 | 2.20 (0.77, 6.30) | .13/.19 |
| rs806368 | TT/TC/CC | 24/50/26 | 17/40/23 | T 49.0 | 45.6 | 0.41 | 1.15 (0.75, 1.74) | .52/.50 |
| rs806370 | CC/CT/TT | 23/50/27 | 16/39/25 | C 48.5 | 43.6 | 0.66 | 1.19 (0.78, 1.83) | .42/.37 |
| rs806380 | GG/GA/AA | 2/26/71 | 1/19/60 | G 15.5 | 13.6 | 0.58 | 1.23 (0.80, 2.13) | .63/.55 |
| rs6454674 | GG/GT/TT | 9/42/49 | 3/26/51 | G 29.6 | 20.4 | 3.80 | 1.64 (1.00, 2.70) | .051/.055 |
| rs2180619 | GG/GA/AA | 5/35/60 | 2/20/58 | G 22.5 | 15.0 | 3.23 | 1.65 (0.95, 2.84) | .072/.076 |
| TRDI (n = 81) | HC (n = 80) | TRDI | HC | |||||
|---|---|---|---|---|---|---|---|---|
| rs806366 | CC/CT/TT | 10/37/34 | 10/36/34 | C 34.6 | 34.9 | 0.0022 | 0.99 (0.62, 1.58) | .96/.97 |
| rs806367 | TT/TC/CC | 3/27/51 | 0/5/75 | T 20.5 | 3.20 | 22.73 | 7.90 (2.99, 20.87) | 1.86e‐006/4.02e‐005 |
| rs806368 | TT/TC/CC | 17/40/24 | 17/40/23 | T 46.15 | 45.6 | 0.0089 | 1.02 (0.66, 1.59) | .92/.57 |
| rs806370 | CC/CT/TT | 15/40/26 | 16/39/25 | C 43.6 | 44.1 | 0.0075 | 0.98 (0.63, 1.54) | .93/.82 |
| rs806380 | GG/GA/AA | 2/23/56 | 1/19/60 | G 17.1 | 13.6 | 0.39 | 1.13 (0.74, 1.65) | .40/.34 |
| rs6454674 | GG/GT/TT | 11/38/32 | 3/26/51 | G 36.7 | 20.4 | 10.07 | 2.26 (1.36, 3.77) | .0015/.0020 |
| rs2180619 | GG/GA/AA | 3/27/51 | 2/20/58 | G 20.5 | 15.0 | 1.65 | 1.46 (0.82, 2.62) | .20/.18 |
CNR1 GenBank version number: NC_000006.11. All significances are shown in bold.
Abbreviations: CI, confidence interval; HC, healthy controls; MDD, major depressive disorder; MDNTR, major depressive patient with no treatment resistance; OR, odds ratio; p‐adjusted, the p value after adjusting for sex and age; SNP, single‐nucleotide polymorphism; TRDI, treatment‐resistant depression with increased inflammatory activity.