TABLE 5.

Associations of CNR1 haplotypes between TRDI and MDNTR patients in relation to treatment response

Haplotype combination	MDNTR frequency %	TRDI frequency %	OR	p value
C‐Ca	1.60	0.70	0.44	.61
C‐Ta	49.4	52.9	1.15	.64
T‐Ca	46.9	43.6	0.88	.66
T‐Ta	2.10	2.80	1.28	.80
Othera	0.01	0.04	2.89	.91
C‐C‐T‐Cb	35.7	15.0	0.33	.003
C‐T‐T‐Cb	6.80	19.5	3.11	.02
T‐C‐C‐Cb	1.50	0.70	0.20	.49
T‐C‐C‐Tb	48.4	51.7	1.14	.65
T‐C‐T‐Cb	4.50	8.20	1.88	.32
T‐C‐T‐Tb	2.00	2.80	1.62	.64
Otherb	1.11	2.10	1.91	.60
A‐Gc	16.1	22.3	1.48	.30
A‐Tc	68.2	60.5	0.71	.28
G‐Gc	13.3	14.0	1.06	.89
G‐Tc	2.50	3.20	1.36	.72
Otherc	0.00	0.02	4.88	.92

CNR1 GenBank version number: NC_000006.11. The significance was in bold.

Abbreviations: HC, healthy control; MDNTR, major depressive patient with no treatment resistance; OR, odds ratio; TRDI, treatment‐resistant depression with increased inflammatory activity.

^a Haplotype block of two loci with strong LD (r ² > 0.8): rs806368–rs806370.

^b Haplotype block of four loci that were in at least moderate LD (r ² > 0.1): rs806366–rs806367–rs806368–rs806370.

^c Haplotype block of two loci that were in moderate LD (r ² > 0.1): rs806380–rs6454674.