Database/resource	Strategy
Embase Ovid	1. crossover procedure.de. 2. double‐blind procedure.de. 3. randomized controlled trial.de. 4. single‐blind procedure.de 5. 1 or 2 or 3 or 4 6. random*.de,ab,ti. 7. factorial*.de,ab,ti. 8. crossover*.de,ab,ti. 9. (cross adj1 over*).de,ab,ti. 10. placebo*.de,ab,ti. 11. (doubl* adj1 blind*).de,ab,ti. 12. (singl* adj1 blind*).de,ab,ti. 13. assign*.de,ab,ti. 14. allocat*.de,ab,ti. 15. volunteer*.de,ab,ti. 16. 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 17. cystic fibrosis.mp. or cystic fibrosis/ 18. CF.mp. 19. (fibrocystic adj disease).tw. 20. mucoviscido$.tw. 21. (cystic$ adj10 fibros$).tw. 22. or/17‐21 23. ehealth.mp. or telehealth/ 24. telemonitoring.mp. or telemonitoring/ 25. internet.mp. or Internet/ 26. smartphone.mp. or mobile phone/ or smartphone/ or telemedicine/ or personal digital assistant/ 27. electronic monitoring.mp. 28. technology/ or technology.mp. 29. app.mp. or mobile application/ 30. email.mp. 31. reminder.mp. 32. (smart adj3 nebulis*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word, candidate term word] 33. ineb.mp. 34. or/23‐33 35. disease exacerbation/ or exacerbation.mp. 36. pulmonary exacerbation.mp. 37. 35 or 36 38. 16 and 22 and 34 and 37 39. limit 38 to (human)
ClinicalTrials.gov www.clinicaltrials.gov	[Advanced Search] SEARCH 1 CONDITION OR DISEASE: cystic fibrosis OTHER TERMS: (technology OR telehealth OR telemedicine OR monitoring OR interactive OR mobile OR web OR internet OR online OR app OR text OR messaging OR telemonitoring OR chip OR chipped) AND exacerbation STUDY TYPE: Interventional Studies (Clinical Trials)   SEARCH 2 CONDITION OR DISEASE: cystic fibrosis OTHER TERMS: (tracking OR tracker OR digital OR bluetooth OR video OR smartphone OR electronic OR computer OR email OR reminder) AND exacerbation STUDY TYPE: Interventional Studies (Clinical Trials)
Australia New Zealand Clinical Trials Registry ANZCTR http://www.anzctr.org.au/default.aspx	[Basic Search]   SEARCH 1 (cystic fibrosis) AND (technology OR telehealth OR telemedicine OR monitoring OR interactive OR reminder)   SEARCH 2 (cystic fibrosis) AND (mobile OR web OR internet OR online OR app OR text)   SEARCH 3 (cystic fibrosis) AND (messaging OR telemonitoring OR chip OR chipped OR tracking OR tracker)   SEARCH 4 (cystic fibrosis) AND (digital OR bluetooth OR video OR smartphone OR electronic OR computer)
WHO ICTRP https://www.who.int/ictrp/en/	Currently unavailable due to Covid‐19.    Search terms to be based on other register search strategies.