Figure 2. The most competent host species for Ross River virus (RRV) transmission in Brisbane change when considering physiological traits alone (A) or also considering ecological traits (B, C).

(A) Estimated physiological response of hosts to experimental infection with RRV, summarized using the area under their estimated titer profiles over time (AUC). In all panels, points show median estimates; error bars are 95% confidence intervals (CIs) that combine the uncertainty from all statistical sub-models used to obtain the estimates presented in that panel (see Figure 1 and Box 1 for these components). Titer profile AUC is used only to quantify host physiological competence, while time-dependent titer profiles (pictured in Appendix 1—figure 1) are used in half-cycle and complete-cycle transmission. The ordering of hosts based on highest (top) to lowest (bottom) physiological competence in A is conserved in B and C to aid visualization of host order changes among panels. (B) Host-to-vector transmission; matrices show the median estimated number of vectors infected by each host species, while the points show infection totals (sums across matrix rows), with error bars. (C) Host-vector-host transmission. As in B, the matrices show estimated median numbers of next-generation host infections for all host species pairs, while the points show sums across rows of the matrices (left plot) and the proportion of infections in the second generation that are in the same species as the original infected individual (center plot).