Table 2.
Univariate and multivariate analyses of survival in EAC patients.
| Variables | Overall survival | Cancer-specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| Log rank X2 | p | HR (95% CI) | p | Log rank X2 | p | HR (95% CI) | p | |
| Sex | 0.497 | 0.481 | 0.757 | 0.384 | ||||
| Female | ||||||||
| Male | ||||||||
| Age (years) | 150.747 | ≤0.001 | ≤0.001 | 119.054 | ≤0.001 | ≤0.001 | ||
| <50 | Reference | Reference | ||||||
| 50–59 | 1.105 (0.962–1.269) | 0.159 | 1.071 (0.930–1.235) | 0.341 | ||||
| 60–69 | 1.198 (1.053–1.362) | 0.006 | 1.118 (0.980–1.275) | 0.097 | ||||
| 70–79 | 1.567 (1.336–1.837) | ≤0.001 | 1.406 (1.191–1.660) | ≤0.001 | ||||
| ≥80 | 2.212 (1.641–2.982) | ≤0.001 | 2.271 (1.675–3.081) | ≤0.001 | ||||
| Race | 6.397 | 0.041 | 0.816 | 6.614 | 0.037 | 0.809 | ||
| Black | Reference | Reference | ||||||
| White | 1.006 (0.816–1.240) | 0.953 | 1.011 (0.813–1.256) | 0.924 | ||||
| Others | 0.938 (0.696–1.263) | 0.672 | 0.938 (0.687–1.279) | 0.684 | ||||
| Marital status | 38.416 | ≤0.001 | 34.036 | ≤0.001 | ||||
| Married | Reference | Reference | ||||||
| Unmarried | 1.113 (1.035–1.197) | 0.004 | 1.107 (1.026–1.195) | 0.009 | ||||
| Insurance | 57.232 | ≤0.001 | ≤0.001 | 53.570 | ≤0.001 | ≤0.001 | ||
| Insured | Reference | Reference | ||||||
| Any Medicaid | 1.229 (1.102–1.371) | ≤0.001 | 1.228 (1.096–1.376) | ≤0.001 | ||||
| Uninsured | 1.393 (1.146–1.693) | 0.001 | 1.314 (1.069–1.615) | 0.009 | ||||
| Grade | 215.503 | ≤0.001 | ≤0.001 | 230.817 | ≤0.001 | ≤0.001 | ||
| I | Reference | Reference | ||||||
| II | 1.148 (0.977–1.349) | 0.094 | 1.155 (0.970–1.376) | 0.106 | ||||
| III | 1.455 (1.028–2.059) | 0.034 | 1.531 (1.064–2.230) | 0.022 | ||||
| IV | 1.558 (1.327–1.829) | ≤0.001 | 1.606 (1.351–1.910) | ≤0.001 | ||||
| Primary site | 18.631 | ≤0.001 | 0.280 | 20.771 | ≤0.001 | 0.229 | ||
| Upper third | Reference | Reference | ||||||
| Middle third | 1.151 (0.822–1.612) | 0.412 | 1.113 (0.784–1.582) | 0.549 | ||||
| Lower third | 1.101 (0.801–1.514) | 0.552 | 1.057 (0.759–1.472) | 0.743 | ||||
| Overlapping lesion | 1.263 (0.891–1.792) | 0.190 | 1.237 (0.860–1.778) | 0.252 | ||||
| AJCC TNM stage (7th) | 1397.996 | ≤0.001 | ≤0.001 | 1508.416 | ≤0.001 | ≤0.001 | ||
| I | Reference | Reference | ||||||
| II | 1.823 (1.559–2.132) | ≤0.001 | 2.147 (1.802–2.558) | ≤0.001 | ||||
| III | 2.567 (2.224–2.963) | ≤0.001 | 3.114 (2.651–3.658) | ≤0.001 | ||||
| IV | 4.243 (3.670–4.904) | ≤0.001 | 5.371 (4.565–6.319) | ≤0.001 | ||||
| Surgery | 1334.023 | ≤0.001 | 1302.575 | ≤0.001 | ||||
| No | Reference | Reference | ||||||
| Yes | 0.366 (0.331–0.405) | ≤0.001 | 0.360 (0.323–0.401) | ≤0.001 | ||||
| Chemotherapy | 70.954 | ≤0.001 | 52.342 | ≤0.001 | ||||
| No/unknown | Reference | Reference | ||||||
| Yes | 0.443 (0.405–0.483) | ≤0.001 | 0.434 (0.396–0.476) | ≤0.001 | ||||
| Radiation | 70.727 | ≤0.001 | 69.422 | ≤0.001 | ||||
| No/unknown | Reference | Reference | ||||||
| Yes | 0.963 (0.890–1.042) | 0.354 | 0.957 (0.881–1.038) | 0.289 | ||||
Note. Univariate analysis, Kaplan–Meier analysis; multivariate analysis, Cox regression analysis; HR, hazard ratio.