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Olaparib decreased colonic proinflammatory cytokine (IL-1β and IL-6) and increased anti-inflammatory IL-10 cytokine levels. Cytokine levels of (a) IL-1β, (b) IL-6, (c) IL-10, and (d) TNF-α. Data combined from 2 separate experiments (n = 9-13) and expressed as mean ± SEM; ns: not significant; ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. VEH: vehicle; TNBS: 2,4,6-trinitrobenzene sulphonic acid; olap (50): 50 mg/kg olaparib.
