Table 3.
miRNAs, epigenetic modifications, and clinical outcome.
| Genes | Epigenetic modifications | Clinical outcomes | References |
|---|---|---|---|
| IL-3, IL-5, and IL-12 | miR-21 | Asthma | [118] |
| IL-12p35 | miR-21 | Severe asthma | [118–120] |
| IRAK1 | miR-146a | Neutrophil migration, IL-5, IL-33 expression | [121, 122] |
| IL-13 | Let-7 | Asthma | [123] |
| IL-5 | miR-1248 | Asthma | [124] |
| TOM1 | miR-126 | Asthma/eosinophil recruitment | [125] |
| S1pr1 | miR-155 | Th2/Th1 response | [126, 127] |
| VEGF/Mpl, SELP, CCL26, TSLP | miR-1 | Th2 inflammation/eosinophil regulation | [128, 129] |
| IL-4 regulator genes | miR-23, miR-27 | IL-4 expression | [130] |
| ADRB2 | miR-16 | Asthma | [131] |
| miR-326/STIM1 axis | circHIPK3 | Asthmatic airway remodeling | [132] |
| PTEN/A20 | miR-19a | Asthma and airway remodeling | [133, 134] |
| VEGF | miR-15a | Asthma | [135] |
| TSLP | miR-19b | Asthma/airway remodeling | [136] |
| MMP-16, ATG7 | miR-192-5p | Airway remodeling | [137] |
| SYK, EGFR | miR-27-b-3p | Pediatric asthma | [138] |
| IL-22 | miR-323-3p | Asthma | [139] |
| HDAC4 | miR-20a-5p | Allergic inflammation/asthma | [140] |