Table 3.
Summary of Findings on Associations Between CIV and Candidate Gene Polymorphisms
| Target | Gene | Snp | Findings | References |
|---|---|---|---|---|
| Serotonin receptor genes | HTR3A | CT haplotype (8046 T > C and 10,627 G > T) | ↓CIV occurrence | Kaiser et al., 200421 |
| HTR3B | rs45460698 (−100-102delAAG deletion variant) | ↑CIV severity | Tremblay et al., 200324 Kang et al., 201717 |
|
| rs3758987 TT(T> C) | ↓CIV occurrence | Cao et al., 201625 | ||
| HTR3C | rs6766410 CC | ↑acute CIV episodes | Fasching et al., 200816 | |
| ↓delayed CIV severity | Pud et al.,201427 | |||
| HTR3D | rs6443930 CC | ↑antiemetic efficacy in serotonin antagonists treated patients | Hammer et al.,201022 | |
| Serotonin transporter | Promoter | rs956304 AG+GG | ↑CIV occurrence | Wei et al., 201830 |
| Tachykinin receptor genes | TACR1 | rs3755468 TT(1323 T > C) | ↑CIV occurrence | Tsuji et al.,202026 |
| Drug metabolizing gene | CYP2D6 | UMs (CYP2D6*1 + duplicate allele) | ↑CIV occurrence | Kaiser et al., 2002;36 Tremblay et al., 2003;24 Perwitasari et al.,201131 |
| PM (Two alleles of CYP2D6*3 CYP2D6*4 CYP2D6*5 CYP2D6*6) | ↓ CIV occurrence and ↑serum tropisetron concentration | Kaiser, 200236 | ||
| Drug transport genes | ABCB1 | rs1045642 TT (3435C> T) | ↓ acute CIV occurrence | Babaoglu et al., 2005;39 He et al.,2014;40 Zoto et al.,201541 |
| ↑ delayed CIV occurrence in olanzapine group | Jin et al.,202142 | |||
| rs20325282 TT (2677G>T/A) | ↓CIV occurrence in granisetron treated patients | Tsuji et al.,2013;43 Tsuji et al.,201744 | ||
| rs20325282 non-GG (2677G>T/A) | ↓delayed CIV occurrence in aprepitant group | Jin et al.,202142 | ||
| rs1128503TT (1236C>T) | ↓ CIV occurrence | Zoto et al., 201541 | ||
| rs1045642; rs20325282; rs1128503 | ↑CIV occurrence in patients who are carriers of the CTG or the CG haplotype | Perwitasari et al., 2011;31 He et al, 201440 | ||
| ATP7B | rs1801244 (valine to leucine change) | ↑CIN occurrence | Lamba et al.,20144 | |
| OCT1 | R61C,C88R,G401S,M420del,G465R | ↓CIV occurrence in tropisetron treated patients who lack active OCT1 allele | Tzvetkov et al., 201247 | |
| DNA repair pathway genes | ERCC1 | rs3212986AA (8092C> A) | ↑acute CIV occurrence | Yokoi et al., 201828 |
| Drug metabolizing gene | DYPD | rs3918290 (c.1905 + 1 G > A) | ↑CIV occurrence in patients with splice donor variant | Lee et al., 201450 |
| rs67376798 TT(Asp949Val) | ↓CIV occurrence | Madi et al.,201451 | ||
| DNA synthesis genes | MTHFR | rs1801133 CC(C677T) | ↓CIV occurrence | Gao et al.,200454 |
| rs1801131 AA(A1298C) | ↑CIV occurrence | Gao et al.,200454 | ||
| DNA repair pathway genes | XRCC1 | rs25487 GG(G28152A) | ↓CIV occurrence | Yang et al.,201355 |
| Transcription factor gene | DRD2 | rs1076560 CC | ↑CIV occurrence | Mukoyama et al., 201623 |
Abbreviation: ↑, increased; ↓, decreased; CIV, chemotherapy-induced vomiting.