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. 2021 Sep 18;15:3965–3978. doi: 10.2147/DDDT.S332847

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© 2021 He et al.

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Overexpression of lncPVT1 and GPX4 impeded ketamine-induced ferroptosis. HepG2 and Huh7 cells were treated with ketamine alone, or with transfection of miR-214-3p inhibitor (inhibitor) or GPX4 overexpressing vectors (OE GPX4). (A and B) Cell viability was detected by CCK-8 assay. The levels of Fe²⁺ (C), lipid ROS (D), and MDA (E) were checked. **p < 0.01.