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. 2020 Dec 12;70(10):1872–1883. doi: 10.1136/gutjnl-2020-322468

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Taxonomic distribution, phylogenetic analysis and sequence characteristics of bacterial OGAs. (A) Proportion of OGA-encoding strains at phylum or genus level. (B) The proportion of different OGA gene copies in different strains. Detail is shown in online supplemental table 1. (C) Upper panel: a phylogenetic tree of OGAs with phylum (inner circle) and conserved domain (outside circle) annotation. Tips of the phylogenetic tree in red represent OGA sequences have homologues in human gut microbiota (>80% identity and >80% of coverage). Lower panel: the human OGAs annotated with conserved domain. (D) Density distribution of identity of OGA homologues according to conserved domain NAGidase. (E) The predicted sub-cellular location of OGAs. OGA, O-GlcNAcase.