Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 10;597(7877):527–532. doi: 10.1038/s41586-021-03855-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 4 — Forest plots demonstrating enrichment of drug targets curated in DrugBank and the Informa Pharmaprojects databases among significant (Tier 1) and nearly significant (Tier 2) binary trait associations, quantitative trait associations, OMIM genes, and GWAS signals. P-values were calculated via Fisher’s exact test (two-sided). Error bars represent 95% confidence intervals of the Odds Ratio. The total numbers of genes per category are as follows: DrugBank-derived (n = 386); Approved from Informa Pharmaprojects (n = 463); Phase III from Informa Pharmaprojects (n = 474); Phase II from Informa Pharmaprojects (n = 1006); Phase I from Informa Pharmaprojects (n = 921); Collapsing – Binary (Tier 1 n = 82; Tier 2 n = 113); Collapsing - Quantitative (Tier 1 n = 269; Tier 2 n = 126); OMIM (n = 3875); GWAS (Tier 1 n = 8975; Tier 2 n = 1717).