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The anti-cancer and anti-inflammatory effects of silymarin. Silymarin can inhibit NF-B by preventing the degradation of inhibitor kappa B (IB), and thus decreases oxidative stress and inflammatory responses. Silymarin inhibits STAT3 and ERK1/2 signaling pathways that can lead to suppression of oncogenesis, cell proliferation, cell migration, and iNOS gene expression.
Figure adapted from [147].
