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. 2021 Sep 22;12:5568. doi: 10.1038/s41467-021-25866-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Example fluorescence micrographs of wild-type and rad27Δ cells expressing Pms1-4GFP show increased levels of foci (white arrows) in the rad27Δ cells. The bar indicates 20 μm. b Quantitation of the average number of Pms1-4GFP foci; error bars represent the standard deviation, the bars indicate the mean of the observations, and the points show the results from each field quantified. The statistical test used was a two-tailed t-test. Deletion of EXO1 or the exo1Δ440-702 truncation cause equivalent levels of Msh2-dependent Pms1-4GFP foci. Deletion of RAD27 causes higher levels of Msh2-dependent of Pms1-4GFP foci than the exo1Δ440-702 truncation, and the exo1Δ440-702 rad27Δ double mutant strain has higher levels of Msh2-dependent Pms1-4GFP foci than either single mutant. The reported experiments were done twice and a minimum of 8 independent fields were captured and quantified per strain analyzed.