Table 1.
MMR defects caused by genetic interactions between exo1Δ440-702, rad27Δ, and pms1-A99V mutations.
| Relevant genotype | hom3-10 reversion rate (×10−9) | lys2-10A reversion rate (×10−9) |
|---|---|---|
| Wild-type | 1.77 [0.76−4.32] (1) | 5.94 [1.31−13.6] (1) |
| msh2Δ | 4200 [3390−7870] (2373) | 136000 [124000−465000] (22896) |
| pms1Δ | 4700 [3140−7230] (2655) | 94300 [73300−117000] (15875) |
| exo1Δ440-702 | 5.33 [4.34−6.54] (3.0) | 17.9 [11.8−23] (3.0) |
| rad27Δ | 171 [93−337] (96.8) | 1830 [1310−2920] (308) |
| exo1Δ440-702 rad27Δ | 562 [337−753] (317) | 6980 [4130−11600] (1176) |
| exo1Δ440-702 rad27Δ msh2Δ | 17700 [8220−45600] (10025) | 244000 [159000−491000] (33216) |
| exo1Δ440-702 rad27Δ pms1Δ | 19500 [8910−35800] (11003) | 197000 [103000−573000] (41127) |
| pms1-A99V | 4.40 [3.06−5.79] (2.5) | 71.9 [64.8−160] (12.1) |
| pms1-A99V exo1Δ440-702 | 336 [239−584] (190) | 15200 [11900−18300] (2559) |
| pms1-A99V rad27Δ | 1360 [1150−1740] (768) | 22500 [16600−31300] (3316) |
| pms1-A99V exo1Δ440-702 rad27Δ | 2260 [1840−2820] (1276) | 43400 [28000−67400] (7307) |
The numbers in square brackets are the 95% confidence intervals. The numbers in parentheses are the fold increase in mutation rate relative to the wild-type strain. Statistical comparison rates are reported in Supplementary Table 1 and Supplementary Table 2. The complete genotypes of the strains used, and the strain identifier numbers are listed in Supplementary Table 3.