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. 2021 Sep 22;11:18849. doi: 10.1038/s41598-021-98086-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of ACLF PMN DEG from our dataset with published enriched neutrophil dataset from systemic lupus erythematosus (SLE) patients (GSE153781). (A) Reanalysis of the GSE153781 showed 387 genes to be upregulated and 343 genes to be downregulated in the neutrophils of SLE versus HC. (B) 198 of 3177 genes and 171 of 2068 genes were common between ACLF versus HC (our dataset) and SLE versus HC; and ACLF versus CLD (our dataset) and SLE versus HC respectively. (C) Recently published ACLF neutrophil dataset (GSE142254) shared 29 of 371 genes with the SLE versus HC (GSE153781).