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. 2021 Sep 22;4:1114. doi: 10.1038/s42003-021-02629-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Functional categories of genes regulated by spermine, spermidine, putrescine and cadaverine. COG categories of the genes showing expression changes in response to each molecule are shown. Regulated genes came from multiple functional classes, and lipid/inorganic ion transport and metabolism genes were highly represented. b Discontinuous heatmap showing induction of the efflux pump genes aceI (PACE family), adeABC (RND family) and amvA (MFS family) and its regulator amvR by different polyamines.