Table 1.
General characteristics of the study population.
| Total (N = 536 patients) |
pCR (N = 133 patients) |
Non-pCR (N = 403 patients) |
P value | |
|---|---|---|---|---|
| Age (y) | ||||
| Mean (± standard deviation) | 45.22 (± 9.91) | 46.13 (± 10.13) | 44.92 (± 9.82) | 0.222 |
| CA 15–3 (U/mL) | 0.024 | |||
| Mean (± standard deviation) | 17.52 (± 23.59) | 13.53 (± 15.41) | 18.84 (± 25.61) | |
| ER (n, %)* | ||||
| Positive | 266 (49.63) | 51 (19.17) | 215 (80.83) | 0.002 |
| Negative | 270 (50.37) | 82 (30.37) | 188 (69.63) | |
| PR (n, %)* | ||||
| Positive | 209 (38.99) | 31 (14.83) | 178 (85.17) | < 0.001 |
| Negative | 327 (61.01) | 102 (31.19) | 225 (68.81) | |
| HER2 (n, %) | ||||
| Positive | 177 (33.02) | 65 (36.72) | 112 (63.28) | < 0.001 |
| Negative | 359 (66.98) | 68 (18.94) | 291 (81.06) | |
| Pathologic diagnosis (n, %) | ||||
| IDC | 481 (89.74) | 127 (26.40) | 354 (73.60) | 0.012 |
| Others | 55 (10.26) | 6 (10.91) | 49 (89.09) | |
| Ki-67 (n, %) | ||||
| 1 + | 102 (19.03) | 14 (13.73) | 88 (86.27) | 0.002 |
| 2 + | 179 (33.40) | 44 (24.58) | 135 (75.42) | |
| 3 + | 128 (23.88) | 30 (23.44) | 98 (76.56) | |
| 4 + | 127 (23.69) | 45 (35.43) | 82 (64.57) | |
| Clinical T-stage at diagnosis (n, %) | ||||
| cT1 | 26 (4.85) | 12 (46.15) | 14 (53.85) | < 0.001 |
| cT2 | 288 (53.73) | 86 (29.86) | 202 (70.14) | |
| cT3 | 178 (33.21) | 25 (14.04) | 153 (85.96) | |
| cT4 | 44 (8.21) | 10 (22.73) | 34 (77.27) | |
| Clinical N-stage at diagnosis (n, %) | ||||
| cN0 | 42 (7.84) | 12 (28.57) | 30 (71.43) | 0.032 |
| cN1 | 108 (20.15) | 38 (35.19) | 70 (64.81) | |
| cN2 | 230 (42.91) | 50 (21.74) | 180 (78.26) | |
| cN3 | 156 (29.10) | 33 (21.15) | 123 (78.85) | |
| NAC regimen (n, %) | ||||
| AC-T | 367 (68.47) | 75 (20.44) | 292 (79.56) | < 0.001 |
| ACTH | 131 (24.44) | 51 (38.93) | 80 (61.07) | |
| AC-T & Platinum | 15 (2.80) | 4 (26.67) | 11 (73.33) | |
| AC | 23 (4.29) | 3 (13.04) | 20 (86.96) | |
*For ER and PR, the Allred scores (0–8) are used in the actual training and validation procedures. For convenience, they are dichotomized in this table.