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. 2021 Sep 22;12:5469. doi: 10.1038/s41467-021-25480-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a EM structure of spike (S1) trimer with each of three chains bound to one C5 nanobody coloured yellow. The other spike monomers are coloured pale cyan, green and purple wheat and throughout and show that all three RDBs are in the down conformation. b Superimposition of C5 onto the spike protein in the two down one up conformation shows that there would be significant clashes that would prevent this interaction.