FIG. 2.

Inactivation of YKU70 or YKU80, but not other DNA maintenance genes, impairs Ty1 retrotransposition frequencies. (A) Transposition frequencies of Ty1 are decreased in a yku70 mutant background, and this is complemented by an episomal plasmid bearing YKU70. Frequencies are shown relative to that of the wild type, which had a mean Ty1 transposition frequency of 1.5 × 10⁻⁴. (B) Ty1 transposition frequencies in yku80, yku70/yku80, rad52, and sgs1 mutant strains relative to that of the wild type. (C) Ty1 transposition frequencies in lig4, rad50, and sir3 mutant strains relative to that of the wild type. (D) Ty1 transposition frequencies in tel1, mec1, and tel1/mec1 mutant strains relative to that of wild-type strain Y661. (E) Ty1 transposition frequencies in yku70, yku70/rad52, and yku70/rad52 strains with Ty1-in2600 relative to that of the wild type.