Table 3.

The joint effect of eGFR and urine protein with cardiovascular mortality

Variables	Cardiovascular mortality
	Male		Female
	HR (95% CI)	P value	HR (95% CI)	P value
eGFR ≥90 + urine protein (−)	Ref	–	Ref	–
90>eGFR≥60+ urine protein (−)	1.93 (0.79 to 4.71)	0.148	2.84 (0.90 to 9.00)	0.076
60>eGFR≥45+ urine protein (−)	2.92 (1.19 to 7.15)	0.019	4.14 (1.29 to 13.3)	0.017
eGFR<45+ urine protein (−)	3.80 (1.53 to 9.46)	0.004	6.88 (2.10 to 22.5)	0.001
eGFR ≥90+ urine protein (+/−, +, ++)	1.57 (0.30 to 8.08)	0.591	3.27 (0.34 to 31. 5)	0.305
90>eGFR≥60+ urine protein (+/−, +, ++)	2.85 (1.14 to 7.10)	0.025	4.72 (1.44 to 15.5)	0.011
60>eGFR≥45+ urine protein (+/−, +, ++)	4.18 (1.68 to 10.4)	0.002	7.72 (2.36 to 25.2)	<0.001
eGFR<45+ urine protein (+/−, +, ++)	6.70 (2.65 to 17.0)	<0.001	16.8 (5.04 to 56.1)	<0.001
eGFR≥90+ urine protein (+++, ++++)*	–	–	–	–
90>eGFR≥ 60+ urine protein (+++, ++++)	5.02 (1.53 to 16.5)	0.008	7.43 (1.49 to 37.0)	0.014
60>eGFR≥45+ urine protein (+++, ++++)	5.71 (1.94 to 16.8)	0.002	17.0 (4.03 to 71.8)	<0.001
eGFR<45+ urine protein (+++, ++++)	10.6 (3.43 to 32.68)	<0.001	55.9 (12.3 to 254)	<0.001

Adjusted for age, BMI, heart disease history, hypertension history, diabetes mellitus history, smoking, drinking and eGFR decline.

*Only three men were in this state, and they were merged into the group of eGFR ≥90+ urine protein (+/−, +, ++) for analysis.

eGFR, estimated glomerular filtration rate.