Table 1.
Clinical and histopathological characteristics of patients stratified by molecular subtype.
| Subtype 1 | Subtype 2 | |||
|---|---|---|---|---|
| n (%) | n (%) | N | p-valuea | |
| Patients | 38 (40) | 58 (60) | 96 | |
| Clinical Center | ||||
| Institut Curie | 31 (42) | 43 (58) | 74 | 0.655b |
| Hospital Garrahan | 6 (33) | 12 (66) | 18 | |
| Hospital Sant Joan de Déu | 1 (25) | 3 (75) | 4 | |
| Sex | ||||
| Female | 17 (35) | 31 (65) | 48 | 0.403c |
| Male | 21 (44) | 27 (56) | 48 | |
| RB1 germline mutation | ||||
| Yes | 14 (70) | 6 (30) | 20 | 7.681 × 10−4 c |
| No | 17 (28) | 44 (72) | 61 | |
| NA | 7 (47) | 8 (53) | 15 | |
| Laterality | ||||
| Bilateral | 12 (75) | 4 (25) | 16 | 1.506 × 10−3 c |
| Unilateral | 26 (33) | 54 (66) | 80 | |
| Age at diagnosis | ||||
| <18 months | 33 (73) | 12 (27) | 45 | 2.132 × 10−9 d |
| 18–36 months | 4 (10) | 38 (90) | 42 | |
| >36 months | 1 (11) | 8 (89) | 9 | |
| Growth pattern | ||||
| Endophytic | 7 (18) | 31 (82) | 38 | 7.332 × 10−4 c |
| Exophytic | 19 (63) | 11 (37) | 30 | |
| Mixed | 6 (46) | 7 (54) | 13 | |
| NA | 6 (40) | 9 (60) | 15 | |
| Tumor diameter (mm) | ||||
| (3.98–6.67] | 1 (50) | 1 (50) | 2 | 0.2094d |
| (6.67–9.33] | 1 (25) | 3 (75) | 4 | |
| (9.33–12] | 7 (50) | 7 (50) | 14 | |
| (12–14.7] | 9 (64) | 5 (36) | 14 | |
| (14.7–17.3] | 9 (27) | 24 (73) | 33 | |
| (17.3–20] | 5 (31) | 11 (69) | 16 | |
| NA | 6 (46) | 7 (54) | 13 | |
| Necrosis | ||||
| Yes | 18 (31) | 40 (69) | 58 | 0.0203c |
| None | 16 (57) | 12 (43) | 28 | |
| NA | 4 (40) | 6 (60) | 10 | |
| Optic nerve invasion | ||||
| None | 12 (48) | 13 (52) | 25 | 0.7467b |
| Prelaminar | 12 (39) | 19 (61) | 31 | |
| Intralaminar | 4 (33) | 8 (66) | 12 | |
| Post-laminar | 4 (31) | 9 (69) | 13 | |
| NA | 6 (40) | 9 (60) | 15 | |
| Choroid and sclera invasion | ||||
| None | 10 (40) | 15 (60) | 25 | 0.6468b |
| Minimal | 10 (48) | 11 (52) | 21 | |
| Deep | 1 (14) | 6 (86) | 7 | |
| Extended | 8 (38) | 13 (62) | 21 | |
| Sclera invasion | 1 (50) | 1 (50) | 2 | |
| NA | 8 (40) | 12 (60) | 20 | |
NA not available, n number in each subtype, N total number.
aSignificant p-value < 0.05.
bTwo-sided Fisher’s exact test.
cChi2 test.
dTwo-sided Kruskal–Wallis rank test.