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. 2021 Sep 22;7:258. doi: 10.1038/s41420-021-00645-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Microvesicles (MVs) or ectosomes are released by direct budding from the plasma membrane. Exosomes are formed by inward invagination of the endosomal limiting membrane, and released after late-sorting endosomes (LSEs) fusion with cell membrane. Exosome contains proteins, DNAs, mRNAs, ncRNAs (miRNAs, long noncoding RNAs and circRNAs) and metabolites. Previously reported EV ncRNAs in CC, OC and EC were listed in the boxes. miRNAs, long noncoding RNAs and circRNAs were respectively labeled in green, orange and blue.