Table 1.

Functions of EV ncRNAs in gynecological malignancies.

Cancer type	Origin	ncRNAs	Function	Pathway/Target	Reference
CC	CC cells	miR-221-3p	Lymphangiogenesis and lymphatic metastasis	VASH1	Zhou et al. [55]
CC	CC cells	miR-221-3p	Proliferation, invasion, migration and angiogenesis	MAPK10	Zhang et al. [56]
CC	CC cells	miR-221-3p	Angiogenesis	THBS2	Wu et al. [57]
CC	Human bone marrow mesenchymal stem cells	miR-144-3p	Proliferation, invasion and migration	CEP55	Meng et al. [70]
CC	CC cells	miR-1468-5p	Immunosuppressive	JAK2/STAT3	Zhou et al. [116]
CC	Cancer-associated fibroblast	miR-10a-5p	Angiogenesis	TBX5 mediated Hh signaling	Zhang et al. [67]
CC	DDP‑resistant Hela cells	HNF1A‑AS1	Proliferation, drug resistance, apoptosis	microRNA-34b/TUFT1	Luo et al. [83]
CC	CC cells	TUG1	Angiogenesis	angiogenesis-related genes	Lei et al. [59]
OC	Hypoxic macrophages	miR-223	Drug resistance	PTEN-PI3K/AKT	Zhu et al. [117]
OC	Human ovarian surface epithelial cells	miR‐124	Extracellular matrix remodeling	SPHK1	Zhang et al. [71]
OC	OC cells	miR-99a-5p	Invasion	HPMCs	Yoshimura et al. [96]
OC	SKOV3	miR-205	Proliferation, migration, invasion, apoptosis and EMT progression	VEGFA	Wang et al. [94]
OC	OC cells or serum	miR-205	Angiogenesis and metastasis	PTEN-AKT	He et al. [95]
OC	MDA-MB-231	miR-454	OC cell growth	PRRT2	Wang et al. [98]
OC	Human adipose mesenchymal stem cells	miRNAs	Apoptosis	pro-apoptotic signaling molecules	Reza et al. [118]
OC	SKOV3	miR-141-3p	Angiogenesis	JAK/STAT3	Masoumi-Dehghi et al. [58]
OC	IOSE-80	miR-34b	Proliferation and EMT	Notch2	Lu et al. [99]
OC	SKOV3/DDP cells	miR-30a-5p	Drug resistance	SOX9	Liu et al. [119]
OC	OC cells	miR-1246	Drug resistance	Cav1/p-gp/M2-type macrophage axis	Kanlikilicer et al. [62]
OC	TWEAK-stimulated macrophages	miR-7	Metastasis	EGFR/AKT/ERK1/2	Hu et al. [101]
OC	Cancer-associated fibroblast cells	miR-98-5p	Proliferation, cell cycle and drug resistance	CDKN1A	Guo et al. [65]
OC	Cancer-associated adipocytes and fibroblasts cells	miR-21	Apoptosis and drug resistance	APAF1	Au Yeung et al. [66]
OC	Mesenchymal stem cells	miR-424	Tumorigenesis and angiogenesis	MYB	Li et al. [69]
OC	Serum	circFoxp1	Drug resistance	miR-22 and miR-150-3p/ CEBPG and FMNL3	Luo et al. [97]
EC	Cancer-associated fibroblasts cells	miR-320a	Proliferation	HIF1α/VEGFA	Zhang et al. [108]
EC	Hypoxic KEL cells	miR-21	M2 polarization	IL-10 and CD206	Xiao et al. [61]
EC	Cancer-associated fibroblasts cells	miR‐148b	Invasion and metastasis	DNMT1	Li et al. [109]
EC	Serum	miR-27a-5p	Migration and invasion	SMAD4	Che et al. [120]
EC	Mesenchymal stem cells	miR-499a-5p	Proliferation, tumor growth and angiogenesis	VAV3	Jing et al. [121]
EC	EC cells	DLEU1	Proliferation, migration, invasion	microRNA/E2F3	Jia et al. [110]