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. 2021 Sep 22;11:18863. doi: 10.1038/s41598-021-98409-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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3D rendering of complete segmentation of every mitochondrion in a small, healthy-looking cone. (A) Three panels represent 90 degree rotations of the ellipsoid of a cone cell showing all the mitochondria. The mitochondria show a range of profiles, though most are long and thin. (B) Mitochondria at the apical end of the ellipsoid terminate with narrow tips. There were also numerous mitochondrial fragments. (C) Those at the distal end were swollen at their tip. (D) Mitochondrial fragments (red) are mostly localised to the apical domain of the ellipsoid. Spheroidal, swollen mitochondria (magenta) are found throughout. (E) Histogram showing the range of mitochondrial volumes in this ellipsoid. The spheroidal mitochondria (magenta) have a greater average volume.