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. 2021 Sep 22;11:487. doi: 10.1038/s41398-021-01613-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Treatment options for clozapine-associated metabolic dysfunctions. BMI body-mass index, cm centimeter, GLP-1RA GLP-1 receptor agonist, HDL high-density lipoprotein, HOMA homeostatic model assessment for insulin resistance, k number of studies, kg kilogram, L long-term, LDL low-density lipoprotein, M medium-term, n number of participants, RCT randomized-controlled trial, S short-term. For continuous outcomes, SMD > 0 means a beneficial outcome for clozapine (e.g. more response or less adverse events. B Treatment options for clozapine-associated hypersalivation. k number of studies, L long-term, M medium-term, n number of participants, RCT randomized-controlled trial, S short-term. For dichotomous outcomes, RR > 1 means a beneficial outcome for clozapine (e.g. more response or less adverse events/dropouts).