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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Lancet Infect Dis. 2021 Mar 23;21(10):e318–e325. doi: 10.1016/S1473-3099(20)30792-1

Figure 2: Malnourished Tanzanian children with tuberculosis have altered rifampin dose-response and increased mortality.

Figure 2:

Scatterplot of peak rifampin concentration versus rifampin dose among 51 pediatric PLWTB in Haydom, Tanzania with body mass index BMI z-scores less than −2, −2 to −4, and less than −4, with greater pharmacokinetic variability in those with lower BMI z-scores. Mortality is indicated in red: 9/51 (17%) died during treatment, with 8/9 (89%) deaths occurring in PLWTB with baseline BMI Z-score less than −2.36 (Cmax: peak concentration; BMI: body mass index; PLWTB: persons living with TB)