Table 3:
Patient-level mean FIB-4 and NFS scores by component of metabolic syndrome, the proportion of patients by metabolic syndrome component with mean FIB-4 and NFS values exceeding the thresholds for advanced fibrosis, and the proportion of patients receiving a NAFLD ICD-9/10 code.
| FIB-4 | NFS | NAFLD Dx | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Mean (SD) | %>1.3 (n) | %>2.67 (n) | Mean (SD) | %>−1.455 (n) | %>0.676 (n) | %(n) | ||
|
Metabolic syndrome component
| ||||||||
| BP > 130/85 | Yes (n=5,820) | 1.38 (1.98) | 38.0% (2,209) | 5.5% (322) | −1.36 (1.49) | 51.3% (2,986) | 8.6% (499) | 5.2% (301) |
| No (n=686) | 1.35 (2.80) | 31.3% (215) | 4.7% (32) | −2.33 (1.48) | 24.9% (171) | 2.9% (20) | 1.8% (12) | |
| p-value | 0.78* | <0.01** | 0.34** | <0.01* | <0.01** | <0.01** | <0.01** | |
|
| ||||||||
| A1c > 6.5% | Yes (n=1,693) | 1.50 (3.09) | 41.1% (696) | 5.6% (95) | −0.35 (1.39) | 80.5% (1,362) | 21.4% (362) | 8.2% (139) |
| No (n=4,813) | 1.34 (1.58) | 35.9% (1,728) | 5.4% (259) | −1.85 (1.37) | 37.3% (1,795) | 3.3% (157) | 3.6% (174) | |
| p-value | 0.03* | <0.01** | 0.72** | <0.01* | <0.01** | <0.01** | <0.01** | |
|
| ||||||||
| Low HDL | Yes (n=4,504) | 1.36 (1.50) | 35.6% (1,603) | 5.8% (260) | −1.37 (1.60) | 51.6% (2,323) | 9.6% (433) | 5.4% (243) |
| No (n=2,002) | 1.42 (3.00) | 41.0% (821) | 4.7% (94) | −1.66 (1.31) | 41.7% (834) | 4.3% (86) | 3.5% (70) | |
| p-value | 0.39* | <0.01** | 0.08** | <0.01* | <0.01** | <0.01** | <0.01** | |
|
| ||||||||
| Trig > 150 | Yes (n=2,729) | 1.39 (1.42) | 38.1% (1,040) | 4.6% (125) | −1.19 (1.45) | 56.0% (1,528) | 9.8% (266) | 7.6% (206) |
| No (n=3,777) | 1.37 (2.45) | 36.6% (1,384) | 6.1% (229) | −1.66 (1.54) | 43.1% (1,629) | 6.7% (253) | 2.8% (107) | |
| p-value | 0.74* | 0.23** | <0.01** | <0.01* | <0.01** | <0.01** | <0.01** | |
|
| ||||||||
| BMI > 30 | Yes (n=3,025) | 1.24 (1.06) | 31.9% (966) | 3.9% (117) | −0.85 (1.46) | 66.1% (1,998) | 14.0% (423) | 6.0% (182) |
| No (n=3,481) | 1.50 (2.66) | 41.9% (1,458) | 6.8% (237) | −1.99 (1.38) | 33.3% (1,159) | 2.8% (96) | 3.8% (131) | |
| p-value | <0.01* | <0.01** | <0.01** | <0.01* | <0.01** | <0.01** | <0.01** | |
Dx=diagnosis. BP=blood pressure (mm Hg). A1c=hemoglobin a1c. HDL=high-density lipoprotein (mg/dL).Trig= Triglycerides (mg/dL). BMI=body mass index (kg/m2).
*
Comparison using 2 sample t-test.
**
Comparison using Chi square test.