TABLE 1.
Susceptibilities of germinated and ungerminated conidia of A. fumigatus to various antifungal agents
| Conidial form used | MIC (μg/ml; geometric mean ± SD)a of:
|
|||
|---|---|---|---|---|
| AMB | ITZ | VCZ | SCH | |
| Ungerminated | 0.406 ± 0.229 | 0.406 ± 0.229 | 0.307 ± 0.120 | 0.267 ± 0.118 |
| Germinated | 0.466 ± 0.079 | 0.287 ± 0.105 | 0.329 ± 0.129 | 0.267 ± 0.079 |
a
Pairwise comparisons of the geometric mean MICs of the same antifungal agent obtained for germinated and ungerminated conidia (n = 10) by two-tailed t-test analysis showed no significant differences. The P values obtained for amphotericin B (AMB), itraconazole (ITZ), voriconazole (VCZ), and SCH56592 (SCH) were 0.7486, 0.0768, 0.6600, and 0.7846, respectively.