Table 1.
Baseline characteristics of patients (n = 26)
| Characteristics | All patients (n = 26) |
Group A: from high to low MAP target (n = 14) |
Group B: from low to high MAP target (n = 12) |
P value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age (year) | 69 [61–75] | 68 [61–75] | 69 [60–75] | 0.7 |
| Male | 21 (80) | 11 (79) | 10 (83) | 0.8 |
| Weight (kg) | 80 [65–94] | 80 [65–95] | 82 [59–100] | 0.8 |
| Body Mass Index | 27 [24–32] | 28 [24–31] | 26 [22–32] | 0.8 |
| Reason for admission | 0.05 | |||
| Medical | 10 (38) | 3 (21) | 7 (58) | |
| Surgical | 16 (62) | 11 (79) | 5 (42) | |
| Antihypertensive treatment | 0.4 | |||
| Calcic inhibitor | 13 (50) | 8 (57) | 5 (42) | |
| Angiotensin converting enzyme inhibitor | 10 (39) | 5 (36) | 9 (75) | |
| Beta-blockers | 11 (42) | 5 (36) | 6 (50) | |
| Diuretic | 2 (8) | 1 (7) | 1 (8) | |
| Comorbidities | 0.8 | |||
| Coronaropathy | 7 (27) | 4 (29) | 3 (25) | |
| Valvular disease | 3 (12) | 1 (7) | 2 (17) | |
| Rhythmic disease | 8 (31) | 5 (36) | 3 (25) | |
| Heart failure | 4 (15) | 3 (21) | 1 (8) | |
| Peripheral arterial disease | 1 (4) | 1 (7) | 0 (0) | |
| Ischemic stroke | 1 (4) | 1 (7) | 0 (0) | |
| Chronic kidney failure | 4 (15) | 3 (21) | 1 (8) | |
| Respiratory disease | 8 (31) | 4 (29) | 4 (33) | |
| Diabetes mellitus | 10 (39) | 6 (43) | 4 (33) | |
| Neoplastic disease | 10 (39) | 7 (50) | 3 (25) | |
| Smoking | 7 (27) | 4 (29) | 3 (25) | |
| Prior kidney function | ||||
| Baseline sCr (µmol/L) | 71 [53–90] | 68 [41–90] | 73 [60–90] | 0.6 |
| Baseline eGFRa (mL/min/1.73 m2) | 92 [75–104] | 92 [74–114] | 89 [76–97] | 0.6 |
| Characteristics at inclusion | ||||
| SOFA score | 9 [7–13] | 9 [6–10] | 9 [7–14] | 0.5 |
| SAPS II score | 52 [36–62] | 48 [34–53] | 61 [41–73] | 0.04 |
| Time from initiation of norepinephrine to inclusion (hours) | 18 [12–24] | 18 [16–24] | 16 [10–23] | 0.3 |
| Baseline KDIGO stage | 0.6 | |||
| 1 | 9 (35) | 4 (29) | 5 (42) | |
| 2 | 13 (50) | 7 (50) | 6 (50) | |
| 3 | 4 (15) | 3 (21) | 1 (8) | |
| sCr (µmol/L) | 124 [75–192] | 143 [116–206] | 105 [69–155] | 0.1 |
| MAP (mmHg) | 71 [65–72] | 71 [69–73] | 67 [65–73 | 0.2 |
Data are expressed as the median [interquartile range] or number (%)
aCalculated using the CKD-EPI formula
bCalculated using the UV/P formula
ARB: angiotensin II receptor blocker; sCr: serum creatinine; SOFA: Sepsis-related Organ Failure Assessment; SAPS II: simplified acute physiology score II; eGFR: estimated glomerular filtration rate; MAP: mean arterial pressure; ICU: intensive care unit