Table 3.
Blood and urine parameters according to mean arterial pressure regimen (n = 26)
| Variables | At inclusion | Low-MAP target period | High-MAP target period | Mean intra-individual difference (95% CI)a | P values for Group-MAP interaction | P values for effect of MAP |
|---|---|---|---|---|---|---|
| Primary endpoint | ||||||
| Creatinine clearance (mL/mn)a | 34 (24) | 32 (31) | 58 (41) | 25 (11, 39) | 0.1 | 0.002 |
| Secondary endpoints | ||||||
| Serum creatinine (µmol/L) | 142 (80) | 150 (85) | 141 (80) | − 10 (− 17, − 3) | 0.5 | 0.03 |
| Urine creatinine (mmol/L) | 7.3 (4.6) | 7.7 (6.1) | 6.5 (4.1) | − 1.1 (− 2.2, 0.05) | 0.2 | 0.06 |
| Urine output (mL/kg/h) | 0.7 (0.5) | 0.8 (0.6) | 1 (0.7) | 0.2 (0, 0.4) | 0.3 | 0.04 |
| Urine sodium (mmol/L) | 44 (30) | 40 (26) | 59 (26) | 6 (0.2, 13) | 0.8 | 0.04 |
| Serum osmolality (mOsm/kg) | 308 (18) | 307 (18) | 306 (15) | − 0.1 (− 2.1, 1.9) | 0.2 | 0.8 |
| Urine osmolality (mOsm/kg) | 436 (141) | 456 (179) | 433 (126) | 3 (− 18, 25) | 0.1 | 0.9 |
| Proteinuria (g/L) | 1.2 (0.8) | 1.1 (0.6) | 1.2 (0.7) | 0.07 (− 0.1, 0.3) | 0.9 | 0.4 |
| Urine–plasma creatinine ratio | 75 (72) | 78 (86) | 70 (71) | − 7 (− 21, 7) | 0.8 | 0.1 |
| Fractional excretion of sodium | 0.9 (1.1) | 1.1 (1.7) | 1.2 (1.4) | 0.02 (− 0.2, 0.3) | 0.8 | 0.8 |
| Fractional excretion of urea | 31 (17) | 32 (13) | 36 (17) | 2.2 (− 1.7, 6.1) | 0.2 | 0.3 |
Data are expressed as the mean (SD) and mean individual difference (IC95%) from low- to high-MAP target period
P values for the within-subject comparisons between the low and the high-MAP target period a multivariate repeated-measures analysis of variance (MANOVA) including the order of assignment of MAP regimes and the KDIGO stage at inclusion as factors
aCalculated using the UV/P formula
MAP: mean arterial pressure; KeGFR: kinetic estimated glomerular filtration rate