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. 2021 Sep 9;12:646043. doi: 10.3389/fimmu.2021.646043

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Copyright © 2021 Ahuja and Lazar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STRING PPI networks representing up- and downregulated biological processes in cytokine-treated vs. non-treated HMC3 cells. (A) Upregulated G1ck vs. G1 (728)/Details provided in Figure 10: Magenta-Mitochondrial gene expression (translation) (36); Purple-Oxidation reduction process (60); Yellow-Immune system process (127); Red-Regulation of cell cycle (63); Green-Proteolysis/phagosome pathway/FCERI mediated NFKB activation (74); Turquoise-ECM organization (27); Blue-Transport/vesicle mediated transport (228); Dark yellow-MAPK family signaling (33); Dark green-Regulation of cell migration (44). (B) Downregulated G1ck vs G1 (403): Red-Cell cycle (94); Green-Chromosome organization (82); Blue-Gene expression/transcription (144); Yellow-DNA repair (35); Dark green-Transcription DNA templated (113); Dark yellow-Transcription RNA pol II (40); Purple-M phase (23); Turquoise-S phase (13); Magenta-Membrane trafficking (24). (C) Upregulated Sck vs S (714): Magenta-Mitochondrial gene expression/translation (mitochondrial ribosomes) (41); Purple-Mitochondrial organization/oxphos, ATP biosynthesis, respiratory electron transport (51); Dark green-Ribosome biogenesis (79); Blue-RNA processing, rRNA/ncRNA (98); Yellow-Viral processes/Interferon signaling (51); Red-Cell cycle (74); Green-Chromosome organization (67); Turquoise-ECM organization (22); Dark yellow-PTMs (69); Brown-Signaling by RTK/cytoskeletal rearrangements, membrane organization, integrin cell surface interactions (28). (D) Downregulated Sck vs S (465): Red-Cell cycle (69); Green-Chromosome organization (77); Blue-Gene expression/transcription (174); Yellow-Mitotic cell cycle process (36); Dark green-Transcription DNA templated (125); Dark yellow-RNA polymerase transcription II; (56) Magenta-Membrane trafficking (35). See also Supplemental File 2 for enlarged images and gene descriptions.