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. 2021 Sep 9;12:714566. doi: 10.3389/fphar.2021.714566

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Copyright © 2021 Chen, Lin, Chen, Wu, Zhu, Ye, Chen, Du and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTX suppresses the inflammatory mediator production of RA-FLS. (A) The relative mRNA expression of IL-1β, IL-6, IL-8, RANKL and OPG were detected by qRT-PCR after treatment with PTX (2.5, 5 and 10 nM). (B) The relative mRNA expression of IL-1β, IL-6, IL-8, MMP-8 and MMP-9 were detected by qRT-PCR after treatment with PTX (5 and 10 nM) and TNF-α (20 ng/ml). Data are expressed as mean ± SD (n = 3). ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001 vs Ctrl group. ^# p < 0.05, ^## p < 0.01, ^### p < 0.001, ^#### p < 0.0001 vs TNF-α group.