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. 2021 Sep 9;12:714566. doi: 10.3389/fphar.2021.714566

FIGURE 4.

FIGURE 4

PTX suppresses the activation of the MAPK and AKT/mTOR pathways. (A–B) MH7A cells were treated with TNF-α and PTX (5 and 10 nM). The protein expression levels of p38, ERK1/2, and JNK and the corresponding phosphorylated proteins were examined by western blotting. (C–D) MH7A cells were treated with TNF-α and PTX (5 and 10 nM). The protein expression levels of phosphorylated/total AKT, mTOR, p70S6K, 4EBP1, and HIF-1α were examined by Western blot analysis. Data are expressed as mean ± SD (n = 3). * p < 0.05, ** p < 0.01 vs Ctrl group. # p < 0.05, ## p < 0.01 vs TNF-α group.