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. 2021 Sep 9;12:714566. doi: 10.3389/fphar.2021.714566

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Copyright © 2021 Chen, Lin, Chen, Wu, Zhu, Ye, Chen, Du and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTX attenuates synovitis in CIA mice. CIA mice were i.p. administered 1.5 mg/kg PTX or solvents every 2 days after the second immunization. (A) Representative images of the paws of the mice in the three groups. (B) The arthritis score was recorded every 3 days after the second immunization. (C) H&E staining of paws was used for histological evaluation. (D) Histological scores of the paws, based on H&E staining. (E) Body weight of mice in the three groups. Data are expressed as mean ± SD (n = 5). ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001 vs Ctrl group. ^# p < 0.05, ^## p < 0.01 vs CIA group.