Figure 3.

Dose–response curves of nsp14 screening hits. The IC₅₀ values were determined for (a) SS148 (0.07 ± 0.006 µM), (b) WZ16 (0.19 ± 0.04 µM), (c) DS0464 (1.1 ± 0.2 µM), (d) DS0466 (3.4 ± 1.4 µM), (e) JL27-56A1 (0.26 ± 0.13 µM), (f) compound 8 (95 ± 6 µM), (g) SAH (0.13 ± 0.03 µM), and (h) MTTR025495 (17 ± 2 µM) by testing their inhibitory effects ranging from 3 nM to 200 µM final concentration. IC₅₀ values are also presented in Table 1. All values are presented as the mean ± standard deviation of three independent experiments (n = 3).