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Structural determinant for SS148 selectivity. A nitrile group (stick) at position 7 of the cofactor adenine ring is compatible with the crystal structure of SAH (wire) bound to (a) nsp14 and (b) BCDIN3D but not (c) G9a. The Van der Waals surface of the cofactor binding pocket is shown as gray mesh. Dose–response curves for SS148 against these proteins with their IC50 values are also shown.
